The ISET (Isolation by Size of Epithelial Tumor Cells) and the CellSearch Methods in Malignant Pleural Mesothelioma

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-02-29

Study Completion Date

2018-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Malignant pleural mesothelioma (MPM) has a growing incidence and in spite of early diagnostic, their outcome remains dismal. The evolution of MPM is often local with rare distant metastases. There is now a sizable body of evidence that metastases could develop from circulating tumor cells (CTC) spread in blood before or during surgery. Thus, sensitive and specific detection of CTC in blood is considered as a potentially relevant predictive biomarker for patients with carcinomas. In exchange, the prognostic value of CTC in MPM has not yet been evaluated.

Indeed, the main goal for preoperative detection of CTC is to identify patients with high risk of recurrence after surgery, in order to perform more adapted therapeutic strategy. Despite several studies reported about CTC detection, methodological aspects concerning sensitivity, specificity and reproducibility have prevented a clear appraisal of their clinical impact. Thus, the aim of our study is to evaluate the presence and the prognostic value of CTC in MPM by a double approach. In our setting, cytopathological analysis of circulating non hematological cells (CNHC), of epithelial origin, isolated according to their size (ISET, Isolation by Size of Epithelial Tumor cells) along with immunomagnetic selection, identification and enumeration of circulating epithelial cells in peripheral blood (CellSearch method) is considered a promising approach.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Evaluation of the Efficacy of Two Guidance Techniques (Standard Injected CT vs Porto-scanner With Angio-CT) for Thermoablation Treatment of Colorectal Cancer Liver Metastases

NCT05665322

Colorectal Cancer Metastatic

TERMINATED NA

Vascularity Impact on the Treatment Outcome in Malignant Pleural Mesothelioma(VITMPM)

NCT02603315

Malignant Pleural Mesotheliomas

COMPLETED

Conventional or Unconventional Lymph Node Dissection During Resection of Intrahepatic Cholangiocarcinoma

NCT02526771

Intrahepatic Cholangiocarcinoma

UNKNOWN NA

A Pilot Study of Perihepatic Phlebotomy During Hepatic Resections

NCT01749332

Liver Cancer

COMPLETED NA

Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal Metastasis

NCT04157322

Colorectal Cancer Stage IV Colorectal Cancer Metastatic Colorectal Cancer, Genetics of +1 more

ACTIVE_NOT_RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pleural Neoplasms Mesothelioma Pneumothorax Parathyroid Neoplasms Benign Tumor of the Thyroid Tumor of the Thyroid

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group patients

Patients with Malignant Pleural Mesothelioma (all stages)

Group Type EXPERIMENTAL

Blood sampling

Intervention Type OTHER

Biological: ISET and CellSearch Methods Sampling of blood - ISET and CellSearch Methods

Control group

Patients with pneumothorax or of benign tumor of the thyroid

Group Type PLACEBO_COMPARATOR

Control Group

Intervention Type OTHER

Biological: ISET and CellSearch Methods Sampling of blood - ISET and CellSearch Methods

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Blood sampling

Biological: ISET and CellSearch Methods Sampling of blood - ISET and CellSearch Methods

Intervention Type OTHER

Control Group

Biological: ISET and CellSearch Methods Sampling of blood - ISET and CellSearch Methods

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

For the patients:

* Age \> 18 years
* Patient having been operated for a strong suspicion of a pleural malignant tumoral lesion corresponding to a primitive pleural mesothelioma
* Signed patient consent

For the control subjects:

* Age \> 18 years
* unhurt of any malignant or mild tumoral pathology or patients that must benefit from a surgical procedure for a benign lesion in other organ than the pleura or a pulmonary non tumoral lesion
* Signed patient consent

Exclusion Criteria

* Patient with histories of cancer or the other synchronous cancer
* Patient with additives treatments
* Patient according to treatments additives others than protocols codified (in particular, platinum navelbine or gemcitabine platinum) for stages II
* HIV, hepatitis B or C infections
* Pregnant women

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No