Estimation of Pulmonary Capillary Blood Volume in Pre- and Postcapillary Pulmonary Hypertension

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

17 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-11-30

Study Completion Date

2018-12-31

Brief Summary

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The aim of the study is to investigate the role of the non-invasive assessment of nitric oxyde (NO) diffusion capacity (DLNO) in the differential diagnosis of different forms of pulmonary hypertension (PH). DLNO alone and in combination with the measurement of carbon monoxide (CO) diffusion capacity (DLCO) may help to differentiate between pre- and postcapillary forms of pulmonary hypertension. This hypothesis is based on the fact that NO has a much higher affinity to hemoglobin as compared to CO and may therefore its decrease may more specifically identify the limiting factors between the alveolar space and the lung capillaries including left heart failure (cardiac edema).

As there are no available published data yet to answer this question investigators aim to perform a small pilot study. The results of this study may allow the planning of a prospective study.

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Detailed Description

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Conditions

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Hypertension Pulmonary

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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precapillary

patients with PH and PAWP\<12mmHg

assessment of DLNO and DLCO

Intervention Type OTHER

postcapillary

patients with PH and PAWP\>18mmHg

assessment of DLNO and DLCO

Intervention Type OTHER

Interventions

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assessment of DLNO and DLCO

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients undergoing right heart catheterization
* patients with clear precapillary PH (PAWP\<12mmHg) or clear postcapillary PH (PAWP\>18mmHg)
* signed informed consent