Clinical, Radiological, Tissue and Biological Phenotyping for the Analysis of the Transition From Physiology to Pathology in Pulmonary Diseases With Pulmonary Hypertension
NCT ID: NCT07184671
Last Updated: 2025-09-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
105 participants
OBSERVATIONAL
2025-09-30
2027-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Patients with chronic pulmonary disease and pulmonary hypertension
Patients on the lung transplant list with chronic pulmonary disease and pulmonary hypertension
blood sampling
22mL peripheral blood will be collected
broncho-alveolar lavage sampling
Collected on resected tissue
lung parenchyma sampling
Collected on resected tissue
Control patients with chronic pulmonary disease without pulmonary hypertension
Control patients with chronic pulmonary disease without pulmonary hypertension on the lung transplant list or with an indication for lung resection surgery for diagnostic or therapeutic purposes.
blood sampling
22mL peripheral blood will be collected
broncho-alveolar lavage sampling
Collected on resected tissue
lung parenchyma sampling
Collected on resected tissue
Control patients without chronic pulmonary disease or pulmonary hypertension
Control patients without chronic pulmonary disease or pulmonary hypertension with an indication for lung resection.
blood sampling
22mL peripheral blood will be collected
broncho-alveolar lavage sampling
Collected on resected tissue
lung parenchyma sampling
Collected on resected tissue
Interventions
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blood sampling
22mL peripheral blood will be collected
broncho-alveolar lavage sampling
Collected on resected tissue
lung parenchyma sampling
Collected on resected tissue
Eligibility Criteria
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Inclusion Criteria
2. Patient who has received information about the study and has not expressed any objection
3. Patient who is a beneficiary or entitled person under a social security scheme
4. Patient requiring thoracic surgery for an acute or chronic acquired pathology with planned resection of lung parenchyma.
5. Group A: patients on the lung transplant list with chronic lung disease and pulmonary hypertension\*.
Group B: control patients with chronic lung disease without pulmonary hypertension on the lung transplant list or with an indication for lung resection surgery for diagnostic or therapeutic purposes.
Group C: control patients without chronic lung disease or pulmonary hypertension with an indication for lung resection.
\*Pulmonary hypertension is defined by a mean resting pulmonary arterial pressure of 20 mmHg and pulmonary vascular resistances \> 2UW and an occlusion pulmonary arterial pressure ≤ 15 mmHg.
Exclusion Criteria
2. Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code (minors, adults under guardianship or trusteeship, patients deprived of their liberty, pregnant or breast-feeding women).
18 Years
ALL
No
Sponsors
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Assistance Publique Hopitaux De Marseille
OTHER
Responsible Party
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Other Identifiers
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2025-A00420-49
Identifier Type: -
Identifier Source: org_study_id
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