Changes of Cardiopulmonary Function After Thrombolysis in Patients With Pulmonary Embolism

NCT ID: NCT04757129

Last Updated: 2024-05-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2024-09-30

Brief Summary

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The investigators expect to enroll about 80-100 acute pulmonary embolism patients treated with thrombolysis in two hospitals. Dynamic changes of cardiopulmonary function after thrombolysis are detected to evaluate which indicators can quickly reflect the effectiveness of thrombolysis.

Detailed Description

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About 80-100 acute pulmonary embolism(APE) patients treated with thrombolysis are enrolled in the First Affiliated Hospital with Nanjing Medical University and Nanjing Drum Town Hospital from January 1, 2020, to June 30, 2024. According to the 2019 ESC guideline, the standards for thrombolysis in APE patients are as follows: within 2 weeks of onset; high-risk pulmonary embolism; medium-high-risk pulmonary embolism with symptoms of aggravation.

Investigators dynamically monitor cardiopulmonary function of participants after thrombolysis, including blood pressure, heart rate, respiratory rate, blood gas analysis, 2-dimensional echocardiography (left and right ventricular diameter, pulmonary artery pressure, interventricular septum) and laboratory tests (cTnT,pro-BNP).participants are divided into two groups: thrombolytic success group and thrombolytic failure group according the previously reported criterion which is evaluated 48h after thrombolysis.

Cardiopulmonary characteristics are analyzed to seek accurate and rapid index to reflect success of thrombolysis.

Conditions

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Acute Pulmonary Embolism

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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thrombolysis success group

Echocardiography was performed 48 hours after thrombolysis to evaluate the success of thrombolysis according to previous report.

No interventions assigned to this group

thrombolysis failure group

Echocardiography was performed 48 hours after thrombolysis to evaluate the success of thrombolysis according to previous report.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* medium-high risk or high risk pulmonary embolism and treated with thrombolysis

Exclusion Criteria

* lack of radiologic evidence to diagnose APE
* death within 48 hours after thrombolytic therapy
* unable to partner treatment and leaving hospitals
* missing other necessary data
* pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bin He

OTHER

Sponsor Role lead

Responsible Party

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Bin He

Attending physician of Affiliated Hospital of Nanjing Medical University

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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the First Affiliated Hospital with Nanjing Medical University

Nanjing, Jiangsu, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Bin He, Master

Role: CONTACT

13770789159

Facility Contacts

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Bin He, Master

Role: primary

13770789159

Other Identifiers

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JSSRMYY-HB-2

Identifier Type: -

Identifier Source: org_study_id

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