Exploratory Metabolomics Study of Exhaled Breath in Pulmonary Embolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

1 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-12-01

Study Completion Date

2024-01-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Pulmonary embolism is a frequent and recurrent pathology, especially in the elderly. It is often preventable, with high mortality and morbidity, making it a major public health issue. The clinical presentation of pulmonary embolism is non-specific and very highly variable, ranging from asymptomatic thrombus diagnosed incidentally to sudden death. The current diagnosis of pulmonary embolism is based on several diagnostic techniques, mainly non-invasive, which should be used sequentially.

We propose to sample the volatile organic compounds using a device that allows them to be trapped on polymer cartridges. Sampling will be performed under monitoring of respiratory pressure and a capnograph to collect alveolar and upper respiratory tract air separately without contamination of the oral cavity or sinuses.

This exploratory metabolic analysis will be non-targeted (analysis of all molecules detectable without a priori).

The main objective of the study is to identify specific metabolic profiles to predict the results of ventilation-perfusion pulmonary tomoscintigraphy in subjects undergoing this examination for suspected acute pulmonary embolism.

Secondary purposes :

* To identify metabolic profiles to be used to predict, in combination with clinical probability scores, the results of ventilation-perfusion pulmonary tomoscintigraphy in subjects undergoing this examination for suspected acute pulmonary embolism.;
* To correlate metabolic profiles with the topography of embolized lung territories

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Development of a Model to Predict the Risk of Venous Thromboembolic Events in Patients With Metastatic Bronchopulmonary Cancer

NCT04196790

Metastatic Bronchopulmonary Cancer

UNKNOWN

Low-dose CT Angiography in the Detection of Acute Pulmonary Embolism: Validation in an Obese Population

NCT04018014

Pulmonary Embolism Obesity CT Scanner

UNKNOWN

Adrenomedullin in Context With Pulmonary Embolism

NCT04875130

Pulmonary Embolism

COMPLETED

Non-invasive Diagnosis of Pulmonary Embolism by Use of Biomarkers in Exhaled Breath Condensate

NCT04010760

Pulmonary Embolism

COMPLETED

Pulmonary Perfusion by Iodine Subtraction Mapping CT Angiography in Acute Pulmonary Embolism

NCT03579849

Pulmonary Embolism

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pulmonary Embolism

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Presence of pulmonary embolism

≥ 1 noninfused and normoventilated segment(s) by pulmonary tomoscintigraphy

Pulmonary embolism diagnosis by nuclear medicine imaging

Intervention Type OTHER

nuclear medicine imaging

No pulmonary embolism

Pulmonary perfusion without anomaly (segmental or sub-segmental) by pulmonary tomoscintigraphy

Pulmonary embolism diagnosis by nuclear medicine imaging

Intervention Type OTHER

nuclear medicine imaging

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Pulmonary embolism diagnosis by nuclear medicine imaging

nuclear medicine imaging

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Male or female, at least 18 years old
* Patients with clinical suspected pulmonary embolism
* Patient willing and able to provide informed consent

Exclusion Criteria

* Contraindications to pulmonary ventilator-perfusion tomoscintigraphy
* All types of thrombolytic or anticoagulant treatment
* Diagnosis of pulmonary embolism established prior to inclusion in the study
* Massive pulmonary embolism (systolic pressure \< 90 mm Hg)
* Pregnancy
* Breastfeeding

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No