Prevalence of Pulmonary Embolism in ICU

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

176 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-12-31

Study Completion Date

2011-04-30

Brief Summary

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The primary objective of this study was to estimate the prevalence of PE among consecutive ICU patients receiving MV who required thoracic computed tomography (CT) with contrast agent injection, regardless of whether PE was suspected clinically. The secondary objectives were to assess the association between PE and DVT, to identify risk factors for VTE, and to determine the outcome of VTE.

Detailed Description

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Background: Pulmonary embolism (PE) produces nonspecific or minimal symptoms in mechanically ventilated (MV) patients, leading to underdiagnosis. We estimated the prevalence of PE and associations with deep vein thrombosis (DVT) among MV patients.

Methods: Consecutive MV patients who required thoracic computed tomography (CT) in a single ICU. Compression ultrasound of the four limbs was performed within 48 hours of inclusion. Curative anticoagulation therapy was given immediately after PE diagnosis.

Conditions

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Pulmonary Embolism Deep Venous Thrombosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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pulmonary embolism, deep venous thrombosis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* all patients requiring invasive MV and thoracic contrast-enhanced CT for any reason

Exclusion Criteria

* a diagnosis of PE before ICU admission,
* allergy to contrast agents,
* and age younger than 18 years.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jean Francois TIMSIT, PU/PH

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Grenoble

Locations

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University hospital of grenoble

Grenoble, , France

Site Status

Countries

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France

References

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Minet C, Lugosi M, Savoye PY, Menez C, Ruckly S, Bonadona A, Schwebel C, Hamidfar-Roy R, Dumanoir P, Ara-Somohano C, Ferretti GR, Timsit JF. Pulmonary embolism in mechanically ventilated patients requiring computed tomography: Prevalence, risk factors, and outcome. Crit Care Med. 2012 Dec;40(12):3202-8. doi: 10.1097/CCM.0b013e318265e461.

Reference Type DERIVED

PMID: 23164766 (View on PubMed)

Other Identifiers

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5891

Identifier Type: -

Identifier Source: org_study_id