Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-11-09

Study Completion Date

2027-05-31

Brief Summary

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Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE). CTEPH is evoked in patients with persistent dyspnea. According to international guidelines, symptomatic patients with perfusion defects on lung scan and Pulmonary Hypertension (PH)-likely transthoracic echo (TTE) must be evaluated in Pulmonary Hypertension (PH)-centers with right heart catheterism, to confirm or rule out the presence of precapillary Pulmonary Hypertension (PH), and precise the group of Pulmonary Hypertension (PH).

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Detailed Description

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However, persistent dyspnea and perfusion defects are frequent after pulmonary embolism (PE), and the accuracy of transthoracic echo (TTE) is not great for precapillary Pulmonary Hypertension (PH).

This study proposed to seek for a specific proteomic pattern in patients admitted for a suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH).

Conditions

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Chronic Thromboembolic Pulmonary Hypertension

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patient with suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH)

* right cardiac catheterization (usual practice)
* a blood sample (inclusion for all patients with suspicion)
* if diagnosis of Chronic thromboembolic pulmonary hypertension confirmed a another bood sample at 6 months

blood sample

Intervention Type BIOLOGICAL

to realize proteomic analysis.

Interventions

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blood sample

to realize proteomic analysis.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Patient with a suspicion of Chronic thromboembolic pulmonary hypertension (CTEPH) with a combination of a perfusion lung scan and transthoracic perfusion scan and transthoracic echocardiography compatible with the diagnosis (according to French recommendations)
* Patients who require a right heart catheterization.
* Patient affiliated or entitled to a social security plan
* Patient having received informed information about the study informed about the study