Pulmonary Endarterectomy Guided by CT Scanning for Patients With Chronic Thromboembolic Pulmonary Hypertension----PEACT

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-01

Study Completion Date

2022-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study is a effectiveness study of the application of high-definition enhanced computed-tomography for patients with chronic thromboembolic pulmonary hypertension(CTEPH).The patients with CTEPH was randomized into 2 groups,precise pulmonary endarterectomy group(guided by enhanced CT scanning) and traditional pulmonary endarterectomy group,the hemodynamic changes tested with right sided heart catherization from baseline to post-operative period and end-point including peri-operative deaths,follow-up mortality,follow-up parameters of ultrasonic cardiogram(UCG),right-sided heart catherization(RHC),nuclear magnetic resonance imaging(MRI),cardiac pulmonary exercise test(CPET) are documented,so as to compare the prognosis between these 2 groups.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

OCT Evaluates the Effects of CTEPH Treated by Scoring Balloon

NCT05480137

CTEPH

UNKNOWN NA

CTEPH Identification an Standard Computerised Tomography Pulmonary Angiography in Pulmonary Embolism Patients

NCT03083093

CTEPH Pulmonary Embolism Early Diagnosis

COMPLETED

Pulmonary Perfusion Heterogeneity in Patients With CTEPH Using Functional PET Imaging

NCT02114047

Chronic Thromboembolic Pulmonary Hypertension

COMPLETED

Thrombolysis Endovascular Treatment of Pulmonary Embolism

NCT03966079

Pulmonary Embolism Acute Pulmonary Embolism

COMPLETED PHASE3

Identification of Criteria of the Success of the Endarterectomy in Chronic Pulmonary Post Embolic Hypertension

NCT00657722

Chronic Thromboembolic Pulmonary Hypertension

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Chronic Thromboembolic Pulmonary Hypertension Pulmonary Embolism

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Precise

precise PEA therapy with the guide of 3-D imaging techniques

Group Type EXPERIMENTAL

3-D CT scanning

Intervention Type DIAGNOSTIC_TEST

For patients in Group 1,precisely analyzed CT scanning and/or pulmonary angiography will be done,and the patients in Group 1 will receive PEA procedure with the guide of precise 3-D imaging techniques

Placebo

traditional PEA therapy solely by surgical probe and traditional CT scanning/pulmonary angiography method

Group Type PLACEBO_COMPARATOR

3-D CT scanning

Intervention Type DIAGNOSTIC_TEST

For patients in Group 1,precisely analyzed CT scanning and/or pulmonary angiography will be done,and the patients in Group 1 will receive PEA procedure with the guide of precise 3-D imaging techniques

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

3-D CT scanning

For patients in Group 1,precisely analyzed CT scanning and/or pulmonary angiography will be done,and the patients in Group 1 will receive PEA procedure with the guide of precise 3-D imaging techniques

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Definite diagnosed with chronic thromboembolic pulmonary hypertension with the right-sided cathrization and pulmonary angiography;
* The computed tomography imaging implied that the location of the embolism could be reached with surgeries;

Exclusion Criteria

* Beyond the age limit described above,or combined with other severe conditions such as severe organ dysfunction and considered contraindicated for surgical therapy by the cardiac surgeons;
* Without the consent by the patient or his/her families;
* Acute pulmonary embolism;
* Pulmonary sarcoma;
* Pulmonary arteritis;
* Combined with cardiogenic pulmonary hypertension or idiopathic pulmonary hypertension;

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No