Predictors of Pulmonary Hypertension in Patients With Advanced Lung Diseases

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-12-31

Study Completion Date

2023-04-30

Brief Summary

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First, the aim of the study was to evaluate the usefulness of echocardiographic parameters for detecting pulmonary hypertension (PH) in patients with advanced lung disease referred for lung transplantation. Second, to assess the prevalence of PH and to identify which hemodynamic, echocardiographic, pulmonary functional test, exercise capacity and biochemical parameters (especially NT-proBNP) have an impact on survival in a cohort of patients with severe lung diseases referred for lung transplantation.

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Detailed Description

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Conditions

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Pulmonary Hypertension

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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mPAP ≥ 25 mmHg

mean pulmonary artery pressure (mPAP) ≥ 25 mmHg (37 patients)

No interventions assigned to this group

mPAP < 25 mmHg

mean pulmonary artery pressure (mPAP) \< 25 mmHg (28 patients).

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* advanced lung disease
* qualification for lung transplantation
* written informed consent
* pulmonary capillary wedge pressure \< 15 mmHg

Exclusion Criteria

* cancer,
* history of idiopathic pulmonary hypertension,
* primary valvular heart diseases,
* coronary artery disease,
* collagen vascular disease,
* history or evidence of left ventricular dysfunction,
* atrial fibrillation,
* increased liver enzyme levels ( 3 times the upper laboratory limit),
* renal dysfunction (estimated glomerular filtration rate \< 60 ml/min/1.73m2)
* patients who didn't write the personal informed consent
* any specific therapy for PH.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No