MedDataX Logo

Evolution of Pulmonary Capillary Blood Volume

NCT ID: NCT00941187

Last Updated: 2013-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-08-31

Study Completion Date

2012-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this monocentric, preliminary study is to assess the evolution of pulmonary capillary blood volume (Vc), measured by the double diffusion nitric oxide/carbon monoxide (NO/CO) method (Guenard et al.; Respir Physiol 1987), from the starting of the anticoagulant therapy to 6 months after, and to search correlations with the evolution of clinical (dyspnea and results of the 6 minutes walking test), biological (BNP; Troponin), echocardiographic (right ventricular dysfunction, pulmonary arterial pressure) and ventilation/perfusion lung scan data.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pulmonary Embolism

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

pulmonary embolism pulmonary capillary blood volume double diffusion NO/CO method

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

patients after a first episode of pulmonary embolism

diffusion NO/CO method

Intervention Type OTHER

pulmonary capillary blood volume (Vc), measured by the double diffusion NO/CO method: this method is to inhale during a deep inspiration with a mixture of helium (8-10%), CO (2000 ppm) and NO (20-40 ppm), the O2 (21%)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

diffusion NO/CO method

pulmonary capillary blood volume (Vc), measured by the double diffusion NO/CO method: this method is to inhale during a deep inspiration with a mixture of helium (8-10%), CO (2000 ppm) and NO (20-40 ppm), the O2 (21%)

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patient with a first episode of symptomatic pulmonary embolism, treated with anticoagulant
* Age from 18 to 75 years-old

Exclusion Criteria

* Confirmed pulmonary embolism in the past
* Massive pulmonary embolism, thrombolytic treatment
* Confirmed left heart systolic dysfunction
* Confirmed asthma, chronic obstructive pulmonary disease or pulmonary fibrosis
* Expected life below 6 months
* Pleural effusion with indication of evacuation
* Bronchopulmonary cancer
* Pulmonary surgery with resection of two lobes minimum
* Predictable incapacity to complete the 6 minutes walking test
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Laurent BERTOLETTI, MD

Role: PRINCIPAL_INVESTIGATOR

CHU de Saint-Etienne

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Departement of pneumology, CHU Saint-Etienne

Saint-Etienne, , France

Site Status

Department of Medicine and Therapeutic, CHU Saint-Etienne

Saint-Etienne, , France

Site Status

Countries

Review the countries where the study has at least one active or historical site.

France

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2008-A01122-53

Identifier Type: OTHER

Identifier Source: secondary_id

0808076

Identifier Type: -

Identifier Source: org_study_id