Quantification of Thrombocytes Number and Function in Patients Undergoing Prolonged Extracorporeal Circulation

NCT ID: NCT02771223

Last Updated: 2016-05-17

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-05-31
• Study Completion Date: 2017-05-31

Brief Summary

Prolonged extracorporeal circulation (ECC) for cardiac surgery results in coagulation abnormalities, most of which related to the direct, time dependent effect of the polymer tubing and the pump rollers on the thrombocytes. Significant evidence demonstrates the effect of the duration of cardiopulmonary bypass on thrombocytes number and function, as well as on postoperative coagulopathy

Detailed Description

Quantification of the effect of ECC duration on blood coagulation and platelet number and function

• Observational study on 20 patients undergoing prolonged ECC
• Blood sampling every 30 minutes for platelet count, platelet adhesion markers and coagulation studies
• Blood test to be performed in Rambam Blood Bank Laboratory

Conditions

Coagulopathy

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

Study group

patients scheduled for prolonged cardiac surgery (over 3 hours anticipated ECC time) with no known coagulation disorders

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• adults over 18 yo
• scheduled for prolonged cardiac surgery requiring ECC time over 3 hours

Exclusion Criteria

• documented coagulopathy
• antiplatelet therapy other then aspirin

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Rambam Health Care Campus

OTHER

Sponsor Role: lead

Responsible Party

Dr. Amit Lehavi MD FANZCA

Director of Pediatric Anesthesia

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

15-645

Identifier Type: -

Identifier Source: org_study_id