Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
16 participants
OBSERVATIONAL
2016-05-31
2018-12-31
Brief Summary
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Large-artery atherosclerosis of the brain-supplying arteries is the assumed underlying cause in 10 to 15% of ischemic stroke, mostly deriving from the extracranial carotid artery. Carotid intima-media thickness (cIMT) measured by 2-dimensional (2D) B-mode ultrasonography and estimation of the overall atherosclerotic plaque burden aids future risk prediction. Arterial wall changes, artery caliber variations, degree of stenosis, local hemodynamic alterations and certain plaque characteristics are important for the evaluation of plaque vulnerability and vascular risk stratification. Transcranial Doppler monitoring (TCDM) is a non-invasive bedside examination eligible for detection of microemboli in the human cerebral circulation.
HYPOTHESIS: Atherosclerotic stenosis and plaque characteristics can be more accurately assessed by the combination of routine 2D ultrasound, contrast enhanced ultrasound (CEUS), and 3-dimensional (3D) ultrasound. TCDM, CEUS and 3D visualization of the carotid plaque improve the differentiation of stroke etiology and quantification of plaque vulnerability, and aid the prediction of future risk for cerebrovascular events in the individual patient.
AIMS: Assessment of prevalence and frequency of Microemboli signals (MES) in unselected patients with cerebral ischemia, the influence of antithrombotic drugs on MES, and the relationship between MES and recurrent stroke or Transient ischemic attack (TIA).
Categorization of atherosclerotic carotid artery disease by use of routine and advanced neurosonographic techniques combined with anamnestic and clinical data.
Development of a visualization solution tailored for 3D visualization of carotid arteries and semi-automatic plaque segmentation.
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Detailed Description
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* Extracranial and transcranial duplexsonography
* Extracranial contrast-enhanced ultrasound
* Extracranial 3D-ultrasound
* Transcranial Doppler monitoring
* Clinical work-up incl. radiological and cardiological procedures, scoring etc
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Symptomatic
Symptomatic carotid artery disease
No interventions assigned to this group
Asymptomatic
Asymptomatic carotid artery disease
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Asymptomatic carotid artery disease
15 Years
ALL
No
Sponsors
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University of Bergen
OTHER
Haukeland University Hospital
OTHER
Responsible Party
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Locations
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Haukeland University Hospital
Bergen, , Norway
Countries
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References
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Aarli SJ, Thomassen L, Waje-Andreassen U, Logallo N, Kvistad CE, Naess H, Fromm A. The Course of Carotid Plaque Vulnerability Assessed by Advanced Neurosonology. Front Neurol. 2021 Aug 20;12:702657. doi: 10.3389/fneur.2021.702657. eCollection 2021.
Other Identifiers
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2015/1217
Identifier Type: -
Identifier Source: org_study_id
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