CT Based Definition of a Tissue Window for Acute Stroke Thrombolysis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2009-01-31

Brief Summary

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Aim of this study is to define a CT-based "tissue window" for stroke thrombolysis. Our primary hypothesis is that

1. patients with a "tissue window" (favourable non-contrast CT (NCCT) scan and an intracranial occlusion on CT angiography (CTA) or perfusion-CT-mismatch" (area of reduced cerebral blood flow (CBF) \> area of reduced cerebral blood volume (CBV)) represent a significant proportion (\> 20%)of acute stroke patients and therefore are an important target group for future interventional studies
2. patients with a "tissue window" suffer an unfavourable outcome (\> 50 % mRS =\>4 at 3 months)if the occluded artery was not recanalized.

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Detailed Description

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Conditions

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Stroke

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* ischemic anterior circulation stroke
* last seen normal \< 12 hours
* stroke severity =\> 3 on the National Institute of Health Stroke Scale
* multimodal CT stroke protocol performed
* informed consent obtained

Exclusion Criteria

* premorbid modified Rankin Scale score \> 3
* contraindications to contrast media application
* pregnancy or breast feeding
* subacute stroke \> 50 % of MCA territory
* CT evidence of non-vascular cause of stroke symptoms

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No