Connectomics in Psychiatric Classification of Bipolar Disorder and Schizophrenia

NCT ID: NCT02756065

Last Updated: 2021-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

220 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-09-30

Study Completion Date

2019-08-31

Brief Summary

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Washington University Early Recognition Center is conducting a research study to examine brain functional connectivity and network patterns in participants with bipolar disorder and schizophrenia.

Detailed Description

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This study extends the assessment of brain connectivity and function, being conducted in the Human Connectome Project (HCP), to psychiatrically ill populations. The HCP consortium has made significant improvements in MRI instrumentation, data acquisition, preprocessing, and analysis. These improvements are currently providing publicly available data on the structure, function, and connectivity of young adult human (age 22-35) brains at unprecedented spatial resolution, temporal resolution, and accuracy. This study will focus on individuals aged 18-40 years who have a diagnosis of either schizophrenia/schizoaffective disorder or bipolar disorder, or are healthy controls. Additionally, similar to the HCP, the investigator will study the effect of genetics on the patterns of brain connectivity in various psychiatric populations. DNA will be collected non-invasively from saliva. Furthermore, this investigator will study cortisol levels in hair samples as an additional assessment to help characterize brain imagining findings.

Conditions

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Bipolar Disorder Schizophrenia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Control

Individuals between 18-30 years old No diagnosis of Bipolar Disorder or Schizophrenia No intervention used

no intervention

Intervention Type OTHER

no intervention is used

Bipolar Disorder

Individuals between 18-30 years old Diagnosis of Bipolar Disorder No intervention used

no intervention

Intervention Type OTHER

no intervention is used

Schizophrenia

Individuals between 18-30 years old Diagnosis of Schizophrenia or Schizoaffective Disorder No intervention used

no intervention

Intervention Type OTHER

no intervention is used

Interventions

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no intervention

no intervention is used

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Between ages 18-30

Exclusion Criteria

* Head Injury
* Unstable Medical Condition
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Washington University Early Recognition Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Daniel Mamah

Role: PRINCIPAL_INVESTIGATOR

Washington University School of Medicine

Locations

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Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Countries

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United States

Other Identifiers

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201404123

Identifier Type: -

Identifier Source: org_study_id

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