Anatomical and Structural Connectivity in Two Psychotic Phenotypes : Periodic Catatonia and Cataphasia
NCT ID: NCT02868879
Last Updated: 2019-10-21
Study Results
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Basic Information
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COMPLETED
162 participants
OBSERVATIONAL
2006-09-25
2019-09-30
Brief Summary
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The investigators will use multimodal structural MRI to assess anatomical connectivity on the one side and its functional consequence on functional connectivity on the other side to assess two phenotypes of psychosis : periodic catatonia and cataphasia in comparison with control subjects.
The coherence between structural and functional anomalies will be especially studied.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Schizophrenia
Quantitative multiparametric and functional MRI
Structural connectivity assessed in the cortex and the white matter using multimodal quantitative parametric imaging (R1, R2, R2\*, DTI, susceptibility, macromolecular proton fraction, cortical thickness, VBM).
Functional connectivity assessed using simple BOLD and combined ASL-BOLD sequences during multiple tasks including motor, language and working memory tasks.
Normal controls.
Quantitative multiparametric and functional MRI
Structural connectivity assessed in the cortex and the white matter using multimodal quantitative parametric imaging (R1, R2, R2\*, DTI, susceptibility, macromolecular proton fraction, cortical thickness, VBM).
Functional connectivity assessed using simple BOLD and combined ASL-BOLD sequences during multiple tasks including motor, language and working memory tasks.
Interventions
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Quantitative multiparametric and functional MRI
Structural connectivity assessed in the cortex and the white matter using multimodal quantitative parametric imaging (R1, R2, R2\*, DTI, susceptibility, macromolecular proton fraction, cortical thickness, VBM).
Functional connectivity assessed using simple BOLD and combined ASL-BOLD sequences during multiple tasks including motor, language and working memory tasks.
Eligibility Criteria
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Inclusion Criteria
* Right handed
* Schizophrenia according to the DSM5
* Either periodic catatonia or cataphasia according to the WKL classification
* Under stable medication regimen (\> 1M)
Exclusion Criteria
* Contraindication to MRI
* Past records susceptible to affect brain integrity
* Severe, unstable medical condition
* Pregnancy
* Patients deprived of their rights
18 Years
65 Years
ALL
Yes
Sponsors
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University Hospital, Strasbourg, France
OTHER
Responsible Party
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Locations
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Service de Psychiatrie, Hôpital Civil, Hôpitaux Universitaires de Strasbourg
Strasbourg, , France
Countries
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References
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Foucher JR, Zhang YF, Roser M, Lamy J, De Sousa PL, Weibel S, Vidailhet P, Mainberger O, Berna F. A double dissociation between two psychotic phenotypes: Periodic catatonia and cataphasia. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Aug 30;86:363-369. doi: 10.1016/j.pnpbp.2018.03.008. Epub 2018 Mar 17.
Other Identifiers
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2898
Identifier Type: -
Identifier Source: org_study_id
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