The Genetic Basis of Inherited Neurologic Deficits in People With Schizophrenia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2025 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-05-31

Study Completion Date

2008-09-30

Brief Summary

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This is a study of the genetic basis of brain dysfunction in people with schizophrenia.

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Detailed Description

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Schizophrenia is a disabling disorder that is associated with specific inheritable neurobiologic deficits. These deficits can cause problems with memory, visual attention, information processing, and other aspects of daily living. Understanding the genetic components of these deficits in people with schizophrenia and their unaffected family members may help uncover the neurobiological basis, risk factors, and heritability of the disease. In addition, the information may serve to create more effective treatments and possibly a cure for the disease. This study will serve to provide information about the genetic basis of known inherited neurobiological deficits in people with schizophrenia. In turn, this may guide further studies on the genetics of schizophrenia.

Participants will attend 2 study visits, each of which will last approximately 4 hours. The first will include blood tests and diagnostic interviews of participating families to evaluate the presence of schizophrenic symptoms. The second study visit will entail four neurocognitive and neurophysiological tests. Participants will first have a pre-pulse inhibition test, which uses electrodes to measure eye blinking. Electrodes will also be placed on participants' head, ears, and around their eyes to measure brain waves. Next, participants will undergo an oculomotor test, during which they will wear glasses fitted with sensors that record eye movement. Participants will then be asked to repeat a list of words, letters, and numbers read by a researcher. Last, participants will undergo a computerized performance test requiring them to watch the computer screen and click a mouse whenever they see a number between 0 and 9. Each study visit will take approximately 4 hours.

Conditions

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Schizophrenia

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Families with at least one member who has schizophrenia

Exclusion Criteria

* N/A

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Dr. David Braff

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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David Braff, MD

Role: STUDY_DIRECTOR

University of California, San Diego

Locations

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University of California Los Angeles

Los Angeles, California, United States

Site Status

University of California, San Diego

San Diego, California, United States

Site Status

University of Colorado Health Sciences Center

Denver, Colorado, United States

Site Status

Harvard University

Boston, Massachusetts, United States

Site Status

Mount Sinai School of Medicine

New York, New York, United States

Site Status

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

University of Washington and VA Puget Sound Health Care System

Seattle, Washington, United States

Site Status

Countries

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United States