Genetics of Schizophrenia

NCT ID: NCT00619437

Last Updated: 2008-02-21

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2008-04-30
• Study Completion Date: 2009-12-31

Brief Summary

Genetic etiology in schizophrenia is widely accepted. However, many chromosomal sites were shown to characterize the families of patients with schizophrenia. This is probably due to the high genetic heterogenity of this illness. Thus, it is important to investigate the genetic factor in relatively genetically homogenous populations. Many studies have indicate that Ashkenazy Jews show relative gentic homogenity. Indeed, the genes responsible for most Mendelian disorders of Jewish peoples have been identified. The study will apply genome-wide mutation screening methods to identify candidate allells in subjects of Ashkenazi Jewish ancestry with multiplex schizophrenia.

Conditions

Schizophrenia

Study Design

• Observational Model Type: FAMILY_BASED
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Age 18+;

2. Meet DSM-IV criteria for Schizophrenia;

3. At least one first-degree relative who Meet DSM-IV criteria for Schizophrenia;

4. Can sign the informed consent form.

Exclusion Criteria

1. Patients suffering from terminal or incurabale disease;

2. Minors, incompetents

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 78 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sheba Medical Center

OTHER_GOV

Sponsor Role: lead

Responsible Party

Mental Health Epidemiology, The Gertner Institute for Epidemiology

Principal Investigators

Michael Bunzel, MD

Role: STUDY_DIRECTOR

Psychiatric ward, Sheba Medical Center

Locations

Sheba Medical Center

Tel Litwinsky, , Israel

Countries

Israel

Central Contacts

Raz Gross, MD, MPH

Role: CONTACT

razg@gertner.health.gov.il

972 3 530 3962

Facility Contacts

Michael Bunzel, MD

Role: primary

Other Identifiers

SHEBA-07-4620-RG-CTIL

Identifier Type: -

Identifier Source: org_study_id