Improving Outcome in Schizophrenia Through Identification of Genetic Risk Factors

NCT ID: NCT00178932

Last Updated: 2025-03-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

37 participants

Study Classification

INTERVENTIONAL

Study Start Date

1998-11-30

Study Completion Date

2024-05-16

Brief Summary

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The goals of this study are to replicate previous findings of genetic predictors of response to clozapine and other antipsychotic drugs.

Detailed Description

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Conditions

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Schizophrenia Schizoaffective Disorder Bipolar Disorder Major Depression

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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1 Outcome in schizophrenia with certain antipsychotic

clozapine

Group Type ACTIVE_COMPARATOR

genetic analysis

Intervention Type PROCEDURE

genetic assay of blood sample drawn with patient's consent

genetic assay

Intervention Type PROCEDURE

genetic assay of blood sample drawn with patient's consent

2 Outcome in schizophrenia with other Antipsychotics

Other Antipsychotics

Group Type ACTIVE_COMPARATOR

genetic analysis

Intervention Type PROCEDURE

genetic assay of blood sample drawn with patient's consent

genetic assay

Intervention Type PROCEDURE

genetic assay of blood sample drawn with patient's consent

Interventions

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genetic analysis

genetic assay of blood sample drawn with patient's consent

Intervention Type PROCEDURE

genetic assay

genetic assay of blood sample drawn with patient's consent

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Patients with the diagnoses of schizophrenia or schizoaffective disorder, and bipolar disorder or major depression with psychotic features, or volunteers with no history of a psychotic disorder.

Exclusion Criteria

Patients with DSM-IV diagnoses other than schizophrenia or schizoaffective disorder, and bipolar disorder or major depression with psychotic features.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Northwestern University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Herbert Y Meltzer, M.D.

Role: PRINCIPAL_INVESTIGATOR

Vanderbilt University Medical Center

Locations

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Psychiatric Hospital at Vanderbilt

Nashville, Tennessee, United States

Site Status

Countries

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United States

Other Identifiers

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9132

Identifier Type: -

Identifier Source: org_study_id

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