Lutonix® Global AV Registry Investigating Lutonix Drug Coated Balloon for Treatment of Native and Synthetic AV Fistulae

NCT ID: NCT02746159

Last Updated: 2023-02-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

320 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-06-07

Study Completion Date

2019-03-09

Brief Summary

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The purpose of this Registry is to enroll patients presenting with clinical and hemodynamic abnormalities in native or synthetic (grafts) arteriovenous (AV) fistulae located in the arm. Subjects will be treated with the Lutonix DCB carrying the CE Mark per current IFU and followed clinically for a minimum of 12 months.

Detailed Description

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This post market registry is intended to demonstrate safety and assess the clinical use and outcomes of the Lutonix DCB in a heterogeneous patient population with dysfunctional native or synthetic AV fistulae in real world clinical practice.

Conditions

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Arteriovenous Fistula

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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Lutonix 035 Drug Coated Balloon PTA Catheter, Model 9004

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Male or non-pregnant, non-breastfeeding female ≥18 years of age;
2. Patient is willing to provide informed consent, and is willing to comply with the protocol-required follow up visits;
3. Native or synthetic (grafts) arteriovenous fistula located in the arm, including central veins, presenting with any clinical, physiological or hemodynamic abnormalities warranting angiographic imaging as defined in the K/DOQI guidelines; and
4. Lesion(s) can be treated with available Lutonix DCB device size matrix per current IFU.

Exclusion Criteria

Patients will be excluded if ANY of the following conditions apply:

1. Patient is currently participating in an investigational drug or device study which has not yet reached its primary endpoint or was previously enrolled into this registry (i.e. Lutonix Global AV registry).
2. Patient has a non-controllable allergy to contrast; or
3. Patient has another medical condition that, which in the opinion of the Investigator, may confound the data interpretation of is associated with a life expectancy insufficient to allow for completion of patient registry procedure and follow up.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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C. R. Bard

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dimitrios Karnabatidis, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital of Patras, Radiology Department

Locations

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LKH Graz

Graz, , Austria

Site Status

Clinique du Pré

Le Mans, , France

Site Status

Clinique Les Fontaines

Melun, , France

Site Status

Institut Montsouris

Paris, , France

Site Status

Uniklinik Giessen und Marburg

Giessen, , Germany

Site Status

Universitätsklinikum Jena

Jena, , Germany

Site Status

University Hospital of Patras

Pátrai, , Greece

Site Status

Azienda Ospedaliera Di Pisa - Ospedale Cisanello

Pisa, , Italy

Site Status

Casa Di Cura Maria Rosaria

Pompei, , Italy

Site Status

San Giovanni Bosco

Torino, , Italy

Site Status

University of Insubria

Varese, , Italy

Site Status

Klinika Chirurgii Naczyniowej University Hospital nr 1

Lublin, , Poland

Site Status

Hospital da Cruz Vermelha

Lisbon, , Portugal

Site Status

NephroCare Portugal, S.A. NephroCare Lumia

Lisbon, , Portugal

Site Status

King Abdullah International Medical Research Center

Riyadh, , Saudi Arabia

Site Status

National University Hospital

Singapore, , Singapore

Site Status

Singapore General Hospital

Singapore, , Singapore

Site Status

Ospedale Regionale di Lugano

Lugano, , Switzerland

Site Status

Buddhist Dalin Tzuchi hospital

Dalin, , Taiwan

Site Status

Chang-Gung Memorial Hospital

Linkou District, , Taiwan

Site Status

Hsin Kong Wu Ho-Su Memorial Hospital

Taipei, , Taiwan

Site Status

Taipei Tzu Chi Hospital

Taipei, , Taiwan

Site Status

Ankara Baskent University

Ankara, , Turkey (Türkiye)

Site Status

Lister Hospital

Leicester, , United Kingdom

Site Status

Barts and The Royal London Hospital

London, , United Kingdom

Site Status

Royal Berkshire hospital

Reading, , United Kingdom

Site Status

Countries

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Austria France Germany Greece Italy Poland Portugal Saudi Arabia Singapore Switzerland Taiwan Turkey (Türkiye) United Kingdom

Other Identifiers

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CL0026-01

Identifier Type: -

Identifier Source: org_study_id

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