Real-World Registry Assessing the Clinical Use of the Lutonix 035 Drug Coated Balloon Catheter

NCT ID: NCT02424383

Last Updated: 2020-05-22

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1005 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-23

Study Completion Date

2019-10-21

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The objective of this patient registry is to assess the clinical use of the Lutonix 035 DCB PTA Catheter in a heterogeneous patient population in a real world and on-label clinical application.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The registry is a prospective, multicenter, single arm post-market real-world registry in the U.S. assessing the clinical use, safety and outcomes of the Lutonix 035 DCB Catheter in the Superficial Femoral Artery (SFA) and Popliteal Arteries (PA). Registry subjects will be followed for up to three year's post-index procedure.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Peripheral Arterial Disease Peripheral Vascular Diseases Arterial Occlusive Diseases

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

PTA (Lutonix® 035 DCB Catheter)

Treatment with the Lutonix 035 DCB will be per the investigational site's standard of care and adhering to the IFU.

Group Type EXPERIMENTAL

PTA (Lutonix® 035 DCB Catheter)

Intervention Type DEVICE

Percutaneous Transluminal Angioplasty (PTA) will involve the insertion of a catheter into one of the femoral arteries. Once the catheter is in place, a tiny balloon on the end of the catheter will be inflated to press against the narrowing (or blockage) in the artery to try to open the blockage, and allow more blood to flow through the artery. The balloon may need to be inflated several times in order for the narrowed area to open up sufficiently to improve the blood flow. The area will be viewed with specialized x-ray or other imaging devices to see if the artery has opened enough.

The Lutonix® DCB through the blood vessel to the narrowed area to be treated.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

PTA (Lutonix® 035 DCB Catheter)

Percutaneous Transluminal Angioplasty (PTA) will involve the insertion of a catheter into one of the femoral arteries. Once the catheter is in place, a tiny balloon on the end of the catheter will be inflated to press against the narrowing (or blockage) in the artery to try to open the blockage, and allow more blood to flow through the artery. The balloon may need to be inflated several times in order for the narrowed area to open up sufficiently to improve the blood flow. The area will be viewed with specialized x-ray or other imaging devices to see if the artery has opened enough.

The Lutonix® DCB through the blood vessel to the narrowed area to be treated.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. The subject provides written informed consent using an Informed Consent Form (ICF) that is reviewed and approved by the Institutional Review Board (IRB) for the site.
2. The subject agrees to comply with the protocol-mandated follow-up procedures and visits.
3. The subject is ≥ 21 years old.
4. The subject must have a lesion(s) that can be treated with available Lutonix 035 DCB Catheter according to IFU.

Exclusion Criteria

1. The subject is unable or unwilling to provide informed consent.
2. The subject is unable or unwilling to comply with the patient registry protocol follow-up procedures and visits.
3. The subject has another medical condition or is currently participating in an investigational drug or an investigational device study that, which, in the opinion of the Investigator, may cause him/her to be non-compliant with the protocol, confounds the data interpretation, or is associated with a life expectancy insufficient to allow for the completion of patient registry procedures and follow-up.
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

C. R. Bard

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Nicholas Shammas, MD

Role: PRINCIPAL_INVESTIGATOR

Midwest Cardiovascular Research Foundation

Edward Woo, MD

Role: PRINCIPAL_INVESTIGATOR

MedStar Regional

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Lake Martin Laser and Vein Institute

Alexander City, Alabama, United States

Site Status

Chandler Regional Medical Center

Chandler, Arizona, United States

Site Status

St. Luke's Hospital- Phoenix

Phoenix, Arizona, United States

Site Status

UCSD Health System

San Diego, California, United States

Site Status

Colorado Heart and Vascular

Lakewood, Colorado, United States

Site Status

Hartford Hospital

Hartford, Connecticut, United States

Site Status

MedStar Health Research Institute

Washington D.C., District of Columbia, United States

Site Status

Research Physicians Network Alliance

Boynton Beach, Florida, United States

Site Status

Bradenton Cardiology Center

Bradenton, Florida, United States

Site Status

Clearwater Cardiovascular & Interventional Consultants

Clearwater, Florida, United States

Site Status

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

Site Status

Sarah Cannon Research Institute, LLC

Jacksonville, Florida, United States

Site Status

Florida Hospital

Orlando, Florida, United States

Site Status

Orlando Health

Orlando, Florida, United States

Site Status

Emory University

Atlanta, Georgia, United States

Site Status

Northside Hospital, Inc

Atlanta, Georgia, United States

Site Status

Vascular Interventional of Thomasville, Associates

Thomasville, Georgia, United States

Site Status

Kaiser Foundation Hospitals

Honolulu, Hawaii, United States

Site Status

Peoria Radiology & Research Foundation

Peoria, Illinois, United States

Site Status

Prairie Education and Research Cooperative

Springfield, Illinois, United States

Site Status

Franciscan St. Francis Health

Indianapolis, Indiana, United States

Site Status

Midwest Cardiovascular Research Foundation

Davenport, Iowa, United States

Site Status

University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States

Site Status

Hutchinson Regional Medical Center - Hutchinson, Inc

Hutchinson, Kansas, United States

Site Status

Maine Medical Center

Portland, Maine, United States

Site Status

MedStar Health Research Institute

Annapolis, Maryland, United States

Site Status

Cape Cod Research Institute

Hyannis, Massachusetts, United States

Site Status

Henry Ford Health System

Detroit, Michigan, United States

Site Status

St. John Hospital and Medical Center

Detroit, Michigan, United States

Site Status

Sparrow Clinical Research Institute

Lansing, Michigan, United States

Site Status

DLP Marquette General Hospital

Marquette, Michigan, United States

Site Status

Cardiac & Vascular Research Center of Northern Michigan/McLaren Northern Michigan Hospital

Petoskey, Michigan, United States

Site Status

Munson Medical Center

Traverse City, Michigan, United States

Site Status

Merit Health Wesley

Hattiesburg, Mississippi, United States

Site Status

Freeman Health System

Joplin, Missouri, United States

Site Status

Hackensack University Medical Center

Hackensack, New Jersey, United States

Site Status

Cardiovascular Associates of Delaware Valley

Haddon Heights, New Jersey, United States

Site Status

Jersey Shore University Medical Center

Neptune City, New Jersey, United States

Site Status

New York Hospital-Queens

Flushing, New York, United States

Site Status

Mount Sinai Beth Israel

New York, New York, United States

Site Status

The Feinstein Institute for Medical Research

New York, New York, United States

Site Status

The Research Foundation for Suny

Syracuse, New York, United States

Site Status

CaroMont Heart Clinical Research

Gastonia, North Carolina, United States

Site Status

LeBauer Cardiovascular Research Foundation

Greensboro, North Carolina, United States

Site Status

Carolina East Health System

New Bern, North Carolina, United States

Site Status

Rex Hospital, Inc

Raleigh, North Carolina, United States

Site Status

Mercy West Hospital

Cincinnati, Ohio, United States

Site Status

Jobst Vascular Institute

Toledo, Ohio, United States

Site Status

Jane Phillips Memorial Medical Center

Bartlesville, Oklahoma, United States

Site Status

University of Oklahoma Health Science Center

Oklahoma City, Oklahoma, United States

Site Status

Integris Baptist Medical Center, Inc

Oklahoma City, Oklahoma, United States

Site Status

Providence Health & Service

Portland, Oregon, United States

Site Status

Lankenau Institute for Medical Research

Bryn Mawr, Pennsylvania, United States

Site Status

Saint Vincent Consultants in Cardiovascular Diseases

Erie, Pennsylvania, United States

Site Status

Heart Institute at Largo

Harrisburg, Pennsylvania, United States

Site Status

Allegheny-Singer Research Institute

Pittsburgh, Pennsylvania, United States

Site Status

Pinnacle Health Cardiovascular Institute

Wormleysburg, Pennsylvania, United States

Site Status

The Miriam Hospital - A Lifespan Partner

Providence, Rhode Island, United States

Site Status

Vascular Access Solutions

Orangeburg, South Carolina, United States

Site Status

Stern Cardiovascular Foundation, Inc

Germantown, Tennessee, United States

Site Status

Stern Cardiovascular Foundation Inc.

Memphis, Tennessee, United States

Site Status

Seton Heart Institute

Austin, Texas, United States

Site Status

Cardiovascular Specialists of Texas

Austin, Texas, United States

Site Status

Methodist Health System Clinical Research Institute

Dallas, Texas, United States

Site Status

El Paso Cardiology Associates, P.A.

El Paso, Texas, United States

Site Status

Houston Methodist Research Institute

Houston, Texas, United States

Site Status

Virginia Cardiovascular Specialists

Richmond, Virginia, United States

Site Status

Sentara Medical Group

Virginia Beach, Virginia, United States

Site Status

Lake Washington Vascular, PLLC

Bellevue, Washington, United States

Site Status

CAMC Health Education and Research Institute

Charleston, West Virginia, United States

Site Status

Bellin Memorial Hospital, Inc

Green Bay, Wisconsin, United States

Site Status

Wisconsin Heart-Meriter

Madison, Wisconsin, United States

Site Status

Columbia St. Mary's, Inc.

Milwaukee, Wisconsin, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

BPV-14-006

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Lutonix Global SFA Registry
NCT01864278 COMPLETED
LEVANT 2 Safety Registry
NCT01790243 COMPLETED NA
AcoArt Ⅰ / SFA China
NCT01850056 COMPLETED NA