Histones and Free-plasma DNA After Cardiac Arrest

NCT ID: NCT02733146

Last Updated: 2017-06-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

42 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-31

Study Completion Date

2016-09-30

Brief Summary

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To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.

Detailed Description

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Conditions

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Heart Arrest Hypothermia Post Cardiac Arrest Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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cardiac arrest patients

Patients who has suffered a cardiac arrest

cardiac arrest

Intervention Type OTHER

Interventions

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cardiac arrest

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Out of hospital cardiac arrest of presumed cardiac cause
* Return of spontaneous circulation (ROSC)
* Glasgow Coma Score \< 8
* Age \> 18 years and \< 80 years

Exclusion Criteria

* \>60 minutes from the circulatory collapse to ROSC
* Time interval \> 4 hours from cardiac arrest to initiation of targeted temperature management
* Terminal illness
* Coagulation disorder
* Unwitnessed asystolia
* Cerebral performance category 3-4 before the cardiac arrest
* Severe persistent cardiogenic shock
* Pregnancy
* Persistent cardiogenic shock (systolic blood pressure \< 80 despite inotropic treatment)
* New apoplexy or intracerebral hemorrhage
* Lack of consent from the relatives
* Lack of consent from the general practitioner
* Lack of consent from the patient if he/she wakes up and is relevant
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Dept of Anesthesiology and Intensive Care and Dept of Clinical Biochemistry, Aarhus University Hospital

Aarhus, Aarhus N, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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AU170878

Identifier Type: -

Identifier Source: org_study_id

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