Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia
NCT ID: NCT02713646
Last Updated: 2023-02-16
Study Results
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Basic Information
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COMPLETED
55 participants
OBSERVATIONAL
2016-11-28
2020-02-01
Brief Summary
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Furthermore, the frequent finding of NVC on MRI studies of asymptomatic patients incited the creation of several strict criteria for the imaging diagnosis of NVC: the vessel must cross perpendicular to the long axis of the nerve, the nerve must be deviated or indented at the root entry zoon (REZ) by the vessel. Alternatively, morphological measurement of the nerve may correlate with the severity of facial pain due to atrophy of the nerve in most cases of ITN, and is likely secondary to the micro-structural abnormalities, such as axonal loss, demyelination, collagen deposition, etc. In this study, cross-sectional area (CSA) and volume (V) of the cisternal trigeminal nerve will be assessed to determine whether it can be a useful biomarker for predicting the degree of ITN.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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patients with primary trigeminal neuralgia
No interventions assigned to this group
healthy subjects
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
35 Years
70 Years
ALL
No
Sponsors
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First Affiliated Hospital Xi'an Jiaotong University
OTHER
Responsible Party
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Principal Investigators
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Ming Zhang, M.D. & Ph.D.
Role: PRINCIPAL_INVESTIGATOR
First Affiliated Hospital Xi'an Jiaotong University
Locations
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3.0-T MRI scanner (Signa HDxt; GE Medical Systems, WI, USA)
Xi'an, Shaanxi, China
Countries
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References
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Leal PR, Barbier C, Hermier M, Souza MA, Cristino-Filho G, Sindou M. Atrophic changes in the trigeminal nerves of patients with trigeminal neuralgia due to neurovascular compression and their association with the severity of compression and clinical outcomes. J Neurosurg. 2014 Jun;120(6):1484-95. doi: 10.3171/2014.2.JNS131288. Epub 2014 Apr 18.
Erbay SH, Bhadelia RA, O'Callaghan M, Gupta P, Riesenburger R, Krackov W, Polak JF. Nerve atrophy in severe trigeminal neuralgia: noninvasive confirmation at MR imaging--initial experience. Radiology. 2006 Feb;238(2):689-92. doi: 10.1148/radiol.2382042214.
Borges A, Casselman J. Imaging the trigeminal nerve. Eur J Radiol. 2010 May;74(2):323-40. doi: 10.1016/j.ejrad.2010.02.006. Epub 2010 Mar 12.
Satoh T, Omi M, Nabeshima M, Onoda K, Date I. Severity analysis of neurovascular contact in patients with trigeminal neuralgia: assessment with the inner view of the 3D MR cisternogram and angiogram fusion imaging. AJNR Am J Neuroradiol. 2009 Mar;30(3):603-7. doi: 10.3174/ajnr.A1409. Epub 2008 Nov 27.
Xu H, Jia L, Wang Y, Han W, Li D, Zhang M, Wang Y. Abnormalities of cortical morphology and structural covariance network in the patients with primary trigeminal neuralgia: a preliminary clinical study. Neurol Sci. 2025 Sep;46(9):4527-4535. doi: 10.1007/s10072-025-08360-y. Epub 2025 Jul 15.
Xu H, Liu Y, Zeng WT, Fan YX, Wang Y. Distinctive cortical morphological patterns in primary trigeminal neuralgia: a cross-sectional clinical study. Neuroradiology. 2024 Feb;66(2):207-216. doi: 10.1007/s00234-023-03257-z. Epub 2023 Nov 25.
Wang Y, Yang Q, Cao D, Seminowicz D, Remeniuk B, Gao L, Zhang M. Correlation between nerve atrophy, brain grey matter volume and pain severity in patients with primary trigeminal neuralgia. Cephalalgia. 2019 Apr;39(4):515-525. doi: 10.1177/0333102418793643. Epub 2018 Aug 7.
Other Identifiers
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XJTU1AF-CRF-2015-028
Identifier Type: -
Identifier Source: org_study_id
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