Role of MRS in Brain Lesions

NCT ID: NCT05565690

Last Updated: 2022-10-04

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 64 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-10-01
• Study Completion Date: 2024-11-01

Brief Summary

Aim of the study is evaluation of accuracy of magnetic resonance spectroscopy in differentiation between neoplastic and non neoplastic lesions and determination the type of neoplasm

Detailed Description

The annual global age-standardized incidence of primary malignant brain tumors is ~3.7 per 100,000 for males and 2.6 per 100,000 for females . Rates appear to be higher more in developed countries (males, 5.8 and females, 4.1 per 100,000) than in less developed countries (males 3.0 and females 2.1 per 100,000). More than half of all brain tumors are Intraparenchymal . Diagnosis of brain lesions and other focal intracranial lesions based on imaging methods alone is still facing a challenging problem. Accurate diagnosis is fundamentally vital for clinical management in patients with brain tumors. CT and standard MRI are the first line imaging modalities in evaluation of brain lesions; however, it does not always provide more precise details and characterization of the lesions whether it is benign or malignant. Conventional imaging techniques do not provide exact information about vascularity, cellularity and metabolism of the mass lesion . Magnetic Resonance Spectroscopy (MR Spectroscopy) is one of the tools used to determine themolecular structures of compounds or to detect the compound presence. MR Spectroscopy provides metabolic information from living tissues. The major brain metabolites detected are choline, creatine, N-acetyl aspartate (NAA), lactate, myoinositol, glutamine, glutamate, lipids and the amino acids leucine and alanine. Brain lesions show abnormal values of these metabolites as compared to normal tissue.Our study aims to determine the accuracy of MRS in differentiation between neoplastic and non neoplastic lesions and determination the type of neoplasm, Discriminating neoplastic from non-neoplastic brain lesions is extremely necessary since a misdiagnosis can lead to a severe effect on neurosurgery and exposure to toxic chemotherapy or radiotherapy, which may cause damage to brain tissues.

Conditions

Brain Lesion (General); Mrs

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

MRS

It is a tool used to determine the molecular structure of compounds or to detect the compound presence , it provides metabolic information from living brain

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• patients with solitary intraaxial brain lesions
• patients with de novo lesions
• Patient age : any age

Exclusion Criteria

• patients with multiple intra-axial brain lesions
• patients with extra-axial brain lesions
• patients with recurrent lesions
• patients receiving chemotherapy or radiotherapy
• patients unfit for surgery

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Ahmed Mohamed Aboelmagd Ahmed

Resident doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ali Ahmed Abd-Elaleem, Lecturer

Role: STUDY_DIRECTOR

Assiut University

Central Contacts

Ahmed Mohamed Aboelmagd, Resident doctor

Role: CONTACT

ahmed.14223789@med.aun.edu.eg

01099474580

Mohamed El-Sayed Mahmoud, Professor

Role: CONTACT

msmluxor@aun.edu.eg

01016077797

Other Identifiers

MRS in brain lesions

Identifier Type: -

Identifier Source: org_study_id