Screening Intracranial Aneurysms With Magnetic Resonance Angiography (MRA) in China

NCT ID: NCT00926172

Last Updated: 2009-12-14

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 4500 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2007-06-30
• Study Completion Date: 2010-06-30

Brief Summary

The Chinese Cerebral Aneurysms Survey is a continuing prospective study among middle-aged and older individuals (35 - 75 years) that aims to determine the prevalence of cerebral intracranial aneurysms in the general population with MRA at 3.0 Tesla (T).

Detailed Description

Cerebral intracranial aneurysms are common. In angiographic and autopsy studies, estimates for prevalence vary between 0.2 and 9.9 percent. The methods used to detect the aneurysms markedly influenced the proportion of aneurysms. Retrospective autopsy studies probably give an underestimation and prospective angiography studies an overestimation of the actual prevalence. Accurate data on the prevalence of intracranial aneurysms are essential in evaluating the results of screening programs for aneurysms in general population.

During the past decade, MRA, as a preferred accuracy modality for noninvasive intracranial vascular imaging at most centers, is playing an increasing role in the evaluation of patients suspected of having intracranial aneurysms. In recurrent study, we have tested that MRA at 3T has excellent sensitivity, accuracy, and correlation with DSA and is comparable to catheter cerebral angiography for the evaluation of patients with intracranial aneurysms (Stroke, in press). Therefore, we examined trends in intracranial aneurysm prevalence with the use of MRA at 3.0T to determine the true prevalence of cerebral intracranial aneurysms in the general middle-aged or elder population.

Conditions

Intracranial Aneurysm

Study Design

• Observational Model Type: ECOLOGIC_OR_COMMUNITY
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Native inhabitants lived in a defined area sites in China
• Aged 35-75 years

Exclusion Criteria

• Less than 35 years old or more than 75 years old
• Incompetent patient who cannot give consent for routine MR Angiography and his/her surrogate decision maker is not available
• Any patients with a contraindication to having a standard MRI examination, such as phase maker, orbital metallic foreign body, etc.

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role: lead

Responsible Party

The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University

Principal Investigators

Ming-Hua Li, MD, PhD

Role: STUDY_CHAIR

The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University

Yong-Dong Li, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University

Locations

The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Yong-Dong Li, MD, PhD

Role: CONTACT

dr_liyongdong@sina.com.cn

0086-21-64844183

Ming-Hua Li, MD, PhD

Role: CONTACT

liminhua@online.sh.cn

0086-21-64844183

Facility Contacts

Yong-Dong Li, MD, Ph.D

Role: primary

dr_liyongdong@sina.com.cn

0086-21-64844183

Ming-Hua Li, MD, Ph.D

Role: backup

liminhua@online.sh.cn

0086-21-64844183

References

Li MH, Cheng YS, Li YD, Fang C, Chen SW, Wang W, Hu DJ, Xu HW. Large-cohort comparison between three-dimensional time-of-flight magnetic resonance and rotational digital subtraction angiographies in intracranial aneurysm detection. Stroke. 2009 Sep;40(9):3127-9. doi: 10.1161/STROKEAHA.109.553800. Epub 2009 Jun 25.

Reference Type: RESULT

PMID: 19556531 (View on PubMed)

Other Identifiers

SAPH001

Identifier Type: -

Identifier Source: secondary_id

CASC1

Identifier Type: -

Identifier Source: org_study_id