MedDataX Logo

Screening Intracranial Aneurysms With Magnetic Resonance Angiography (MRA) in China

NCT ID: NCT00926172

Last Updated: 2009-12-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

4500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-06-30

Study Completion Date

2010-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The Chinese Cerebral Aneurysms Survey is a continuing prospective study among middle-aged and older individuals (35 - 75 years) that aims to determine the prevalence of cerebral intracranial aneurysms in the general population with MRA at 3.0 Tesla (T).

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Cerebral intracranial aneurysms are common. In angiographic and autopsy studies, estimates for prevalence vary between 0.2 and 9.9 percent. The methods used to detect the aneurysms markedly influenced the proportion of aneurysms. Retrospective autopsy studies probably give an underestimation and prospective angiography studies an overestimation of the actual prevalence. Accurate data on the prevalence of intracranial aneurysms are essential in evaluating the results of screening programs for aneurysms in general population.

During the past decade, MRA, as a preferred accuracy modality for noninvasive intracranial vascular imaging at most centers, is playing an increasing role in the evaluation of patients suspected of having intracranial aneurysms. In recurrent study, we have tested that MRA at 3T has excellent sensitivity, accuracy, and correlation with DSA and is comparable to catheter cerebral angiography for the evaluation of patients with intracranial aneurysms (Stroke, in press). Therefore, we examined trends in intracranial aneurysm prevalence with the use of MRA at 3.0T to determine the true prevalence of cerebral intracranial aneurysms in the general middle-aged or elder population.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Intracranial Aneurysm

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Magnetic resonance angiography Intracranial aneurysm cerebral aneurysm unruptured aneurysm Epidemiology Magnetic Resonance Imaging

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

ECOLOGIC_OR_COMMUNITY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Native inhabitants lived in a defined area sites in China
* Aged 35-75 years

Exclusion Criteria

* Less than 35 years old or more than 75 years old
* Incompetent patient who cannot give consent for routine MR Angiography and his/her surrogate decision maker is not available
* Any patients with a contraindication to having a standard MRI examination, such as phase maker, orbital metallic foreign body, etc.
Minimum Eligible Age

35 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Ming-Hua Li, MD, PhD

Role: STUDY_CHAIR

The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University

Yong-Dong Li, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Yong-Dong Li, MD, PhD

Role: CONTACT

Phone: 0086-21-64844183

Email: [email protected]

Ming-Hua Li, MD, PhD

Role: CONTACT

Phone: 0086-21-64844183

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Yong-Dong Li, MD, Ph.D

Role: primary

Ming-Hua Li, MD, Ph.D

Role: backup

References

Explore related publications, articles, or registry entries linked to this study.

Li MH, Cheng YS, Li YD, Fang C, Chen SW, Wang W, Hu DJ, Xu HW. Large-cohort comparison between three-dimensional time-of-flight magnetic resonance and rotational digital subtraction angiographies in intracranial aneurysm detection. Stroke. 2009 Sep;40(9):3127-9. doi: 10.1161/STROKEAHA.109.553800. Epub 2009 Jun 25.

Reference Type RESULT
PMID: 19556531 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

SAPH001

Identifier Type: -

Identifier Source: secondary_id

CASC1

Identifier Type: -

Identifier Source: org_study_id