A Study on a Multidimensional Prediction Model for Rupture Risk of Unruptured Intracranial Aneurysms

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-01

Study Completion Date

2021-12-31

Brief Summary

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This is a registry study on a multidimensional prediction model for rupture risk of unruptured intracranial aneurysms in China.

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Detailed Description

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This subsequent program China Intracranial Aneurysm Project - 2 (CIAP-2) will comprise screening of 500 patients from the UIA cohort (CIAP-1) and focus on hemodynamics factors, high resolution magnetic resonance imaging (HRMRI), genetic factors and biomarkers. Possible risk factors for rupture of UIA, including genetic factors, biomarkers, HRMRI, and hemodynamic will be analyzed. The first project of the China Intracranial Aneurysm Project (CIAP-1: Chaired by the Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China) will establish a prospective cohort of 5000 patients with UIA from 20 centers in China, and collect baseline information for each patient. Multidimensional data will be acquired in follow-up assessments. Statistically significant clinical features in the UIA cohort will also be analyzed and integrated into this model for predicting risk of UIA rupture. After the model has been set up, the resultant evidence-based prediction will be used to provide a preliminary theoretical basis for the treatment of aneurysms at high risk of rupture.

Conditions

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Intracranial Aneurysm

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* At least 1 UIA that is untreated and confirmed by imaging: Computed tomography angiography (CTA), magnetic resonance angiography (MRA) and digital subtraction angiography (DSA). Regardless of the presence of clinical symptoms
* Patient currently has the ability to live independently, and a modified Ranking Score less than or equal to 3 points
* Older than 14 years of age
* Patient or relatives agreed to sign the consent form

Exclusion Criteria

* Subarachnoid hemorrhage of unknown origin
* Presence of other intracranial vascular malformations, such as cerebral arteriovenous malformation (AVM) or cerebral arteriovenous fistula (AVF)
* Intracranial and other malignant tumors
* Fusiform, traumatic, bacterial or dissecting aneurysm
* Patients with severe mental illness who are unable to communicate
* Patients with other diseases or poor general condition who are expected to survive less than 1 year
* Patients with intracranial aneurysms who have joined other similar research institutions
* Patients who refused follow-up

The definition of modified Ranking Score:

* 0 Completely silent
* 1 Despite symptoms, but not visibly disabled, can complete all regular duties and activities
* 2 Mild disabilities, not all activities previously possible, but can deal with personal affairs without need of assistance
* 3 Moderate disability requires some help, but walking does not need assistance;
* 4 Severe disabilities, unable to walk independently, no others can not meet their needs
* 5 Severely disabled, bedridden, Urine, requiring continuous care and care;
* 6 Mortality

Minimum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Xinjian Yang, MD

Vice Chair of Department of Interventional Neuroradiology of Beijing Neurosurgical Institute

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xinjian Yang, MD

Role: PRINCIPAL_INVESTIGATOR

Beijing Neurosurgical Institute and Beijing Tiantan Hospital affiliated to Capital Medical University，China

Locations

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