Intracranial Artery Stenosis Magnetic Resonance Imaging: Aetiology and Progression
NCT ID: NCT03417063
Last Updated: 2018-01-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
300 participants
OBSERVATIONAL
2017-10-14
2022-03-25
Brief Summary
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High-resolution magnetic resonance imaging (HR-MRI) has been widely used to assess ICAS diseases. The different etiologies of ICAS are differentiable by MR-MRI according to the features of location, shape, signal pattern, remodeling, and contrast enhancement. Investigators have proved that HR-MRI is a reproducible technique that may be reliably utilized to monitor the changes of ICAD during natural follow-up or medical treatment.
The ICASMAP (Intracranial Artery Stenosis MR Imaging: Aetiology and Progression) is a prospective, cross-sectional, observational, and multicenter study. The objectives of ICASMAP are to determine: 1) the spectrum of etiology of ICAS in stroke patients; and 2) the influence factors for progression of ICAD. A total of 300 patients with symptomatic stenotic disease in intracranial arteries (stenosis range: 30%-99%) will be recruited within two weeks after symptom onset from 18 different hospitals across Beijing-Tianjin-Hebei region in China within 1 year. All the patients will undergo HR-MRI for intracranial arteries at baseline, one-year, and two-years. The clinical risk factors will be collected and blood draw will be conducted. The ICASMAP study may help to improve the precise diagnosis and intervention of ICAS and stroke prevention.
Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_ONLY
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients with evidence of may causing cardiac thrombosis disease
* Patients with claustrophobia
* Patients with contraindications to MR imaging
* Patients with heart or respiratory failure
* Patients with renal insufficiency (serum creatinine \>133umol/L)
* Patients with serious disturbance of consciousness
* Patients with brain tumors
* Patients with cerebral hemorrhage
* Pregnant woman or plan to pregnant within recent 2 years
18 Years
80 Years
ALL
No
Sponsors
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Xuanwu Hospital, Beijing
OTHER
Beijing Tiantan Hospital
OTHER
Beijing Hospital
OTHER_GOV
309th Hospital of Chinese People's Liberation Army
OTHER
Navy General Hospital, Beijing
OTHER
First Hospitals affiliated to the China PLA General Hospital
OTHER_GOV
Beijing Huairou Hospital
OTHER
Beijing Pinggu District Hospital
OTHER
Beijing Shuyi Hospital
OTHER
Tianjin First Central Hospital
OTHER
Tianjin 4th Centre Hospital
UNKNOWN
Tianjin Union Medical Center
OTHER
Hebei Medical University Third Hospital
OTHER
Affiliated Hospital of Chengde Medical University
OTHER
Tangshan Gongren Hospital
OTHER
The First Affiliated Hospital of Hebei North University
OTHER
Cangzhou People's Hospital
OTHER
Harrison International Peace Hospital
OTHER
Tsinghua University
OTHER
Responsible Party
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Xihai Zhao
Professor
Principal Investigators
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Xihai Zhao, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Tsinghua University
Locations
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Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University
Beijing, , China
Countries
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Central Contacts
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Facility Contacts
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Le He, MD
Role: primary
References
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Wang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group. Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis (CICAS) Study. Stroke. 2014 Mar;45(3):663-9. doi: 10.1161/STROKEAHA.113.003508. Epub 2014 Jan 30.
Ahn SH, Lee J, Kim YJ, Kwon SU, Lee D, Jung SC, Kang DW, Kim JS. Isolated MCA disease in patients without significant atherosclerotic risk factors: a high-resolution magnetic resonance imaging study. Stroke. 2015 Mar;46(3):697-703. doi: 10.1161/STROKEAHA.114.008181. Epub 2015 Jan 27.
Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O'Donnell MJ, Sacco RL, Connolly SJ; Cryptogenic Stroke/ESUS International Working Group. Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol. 2014 Apr;13(4):429-38. doi: 10.1016/S1474-4422(13)70310-7.
Wang Y, Xu J, Zhao X, Wang D, Wang C, Liu L, Wang A, Meng X, Li H, Wang Y. Association of hypertension with stroke recurrence depends on ischemic stroke subtype. Stroke. 2013 May;44(5):1232-7. doi: 10.1161/STROKEAHA.111.000302. Epub 2013 Feb 26.
Gorelick PB, Wong KS, Bae HJ, Pandey DK. Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier. Stroke. 2008 Aug;39(8):2396-9. doi: 10.1161/STROKEAHA.107.505776. Epub 2008 Jun 5.
Choi YJ, Jung SC, Lee DH. Vessel Wall Imaging of the Intracranial and Cervical Carotid Arteries. J Stroke. 2015 Sep;17(3):238-55. doi: 10.5853/jos.2015.17.3.238. Epub 2015 Sep 30.
Mossa-Basha M, Hwang WD, De Havenon A, Hippe D, Balu N, Becker KJ, Tirschwell DT, Hatsukami T, Anzai Y, Yuan C. Multicontrast high-resolution vessel wall magnetic resonance imaging and its value in differentiating intracranial vasculopathic processes. Stroke. 2015 Jun;46(6):1567-73. doi: 10.1161/STROKEAHA.115.009037. Epub 2015 May 7.
Han Y, Zhang R, Yang D, Li D, Han H, Qiao H, Chen S, Wang Y, Yu M, Hong Y, Wang Z, Zhao X, Liu G. Risk Factors for Asymptomatic and Symptomatic Intracranial Atherosclerosis Determined by Magnetic Resonance Vessel Wall Imaging in Chinese Population: A Case-Control Study. Ther Clin Risk Manag. 2022 Jan 12;18:61-70. doi: 10.2147/TCRM.S335401. eCollection 2022.
Other Identifiers
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D171100003017003
Identifier Type: -
Identifier Source: org_study_id