Investigation of Hemodynamics and Radiomics Based on High Resolution Magnetic Resonance Imaging for Predicting the Outcomes of Intracranial Dissecting Aneurysm

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

208 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-01

Study Completion Date

2027-12-31

Brief Summary

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This study aims to conduct a comprehensive analysis by integrating clinical factors, aneurysm morphological characteristics, and factors reflecting pathophysiological processes (such as hemodynamic and radiomics features), in order to explore the hemodynamic mechanisms associated with the progression of intracranial dissecting aneurysms. Furthermore, artificial intelligence algorithms will be employed to develop and validate an intelligent risk prediction model for the progression and outcomes of intracranial dissecting aneurysms.

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Detailed Description

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Conditions

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Cerebrovascular Disease Intracranial Aneurysm Intracranial Arterial Dissection

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Control Group (Non-progression Group)

Imaging progression of intracranial dissecting aneurysms during follow-up

No interventions assigned to this group

Experimental Group (Progression Group)

Imaging progression of intracranial dissecting aneurysms during follow-up

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Intracranial dissecting aneurysm clearly diagnosed by DSA and high-resolution MRI imaging (according to the imaging diagnostic criteria proposed in the Chinese Expert Consensus on Imaging Diagnosis of Intracranial Arterial Dissection)
2. patients managed with conservative treatment and follow-up
3. patients who agree and sign a written informed consent form

Exclusion Criteria

1. Arteritis, fibromuscular dysplasia, iatrogenic or traumatic pseudoaneurysms
2. Contraindications to MRI examination (such as claustrophobia or metallic implants), or contraindications to cerebral angiography (such as iodine contrast allergy)
3. Dissecting aneurysms extending from the extracranial segment to the intracranial segment, or cases with concomitant intracranial atherosclerotic plaques in the affected vessels
4. Patients who refuse MRI examination
5. Patients with severe comorbid diseases and an expected survival time of less than 2 years due to these conditions
6. Patients without follow-up HR-MRI imaging for any reason

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No