Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-01

Study Completion Date

2027-12-31

Brief Summary

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The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.

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Detailed Description

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Cerebrovascular disease is the most common cause of death worldwide. There is a close link in structure and function between the intracranial large arteries and cerebral small vessels. Moreover, growing evidences have demonstrated that large artery atherosclerosis often coexists with small vessel disease, which may deteriorate the clinical outcomes of stroke and dementia. The mutual feedback mechanism between them is not fully understood. The present study focuses on the mechanism of mutual feedback between large artery atherosclerosis and cerebral small vessel disease by using magnetic resonance imaging. The study may provide biomarkers for the early prevention and treatment of cerebrovascular disease.

Conditions

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ICAS - Intracranial Atherosclerosis Cerebral Small Vessel Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Intracranial atherosclerosis and small vessel disease

Patients diagnosed with intracranial large artery atherosclerosis and cerebral small vessel disease based on imaging screening.

Magnetic resonance imaging

Intervention Type DIAGNOSTIC_TEST

Imaging diagnostics mainly based on Magnetic resonance imaging.

Interventions

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Magnetic resonance imaging

Imaging diagnostics mainly based on Magnetic resonance imaging.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* At least one intracranial artery ≥ 50% atherosclerotic stenosis
* Modified Rankin Scale \< 2
* Mini-mental State Examination \> 24

Exclusion Criteria

* Concurrent ipsilateral extracranial artery ≥ 50% stenosis
* Pregnant women
* Contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)

Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No