Brain Imaging in Cerebral Venous Outflow Disturbance

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-01

Study Completion Date

2024-12-31

Brief Summary

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Cerebral venous outflow disturbance can lead to cerebral hemodynamic disturbances, altered cerebrospinal fluid dynamics, cerebral venous blood stasis, increased cerebral venous pressure and decreased cerebral perfusion, cerebral white matter sparing-like changes, and widening of retinal vessel diameter. These changes are associated with numerous neurological signs and symptoms. Therefore, understanding the brain structural and functional changes in patients with cerebral venous outflow disturbance is essential to provide specific imaging evaluation indicators and new diagnosis and treatment methods for patients with cerebral venous return disorders.

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Detailed Description

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Cerebral venous outflow disturbance can lead to cerebral hemodynamic disturbances, altered cerebrospinal fluid dynamics, cerebral venous blood stasis, increased cerebral venous pressure and decreased cerebral perfusion, cerebral white matter sparing-like changes, and widening of retinal vessel diameter. These changes are associated with numerous neurological signs and symptoms. A number of central nervous system disorders such as transient global amnesia, transient monocular blindness, primary labor headaches, and even Parkinson's have been reported to be closely associated with internal jugular vein stenosis. Other common clinical manifestations include sleep disturbances, tinnitus, tinnitus, headache, visual impairment, optic papilledema, hearing loss, cognitive decline and neck discomfort and even autonomic dysfunction. The main objective of this study is to investigate the structural and functional network changes in patients with cerebral venous outflow disturbance using different brain imaging techniques, to clarify the correlation between symptoms of cerebral venous outflow disturbance and brain structure and function; to identify areas with corresponding structural and functional changes in patients with cerebral venous outflow disturbance and or comorbid symptoms, and to provide specific imaging assessment indicators and new diagnostic and treatment tools for patients with cerebral venous outflow disturbance and comorbid symptoms.

Conditions

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Abnormal Cerebral Venous Sinus Morphology Internal Jugular Vein Stenosis Image

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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CVOD-WS

Cerebral Venous Outflow Disturbance with symptoms such as tinnitus cerebri，somnipathy ，anxiety ，depression and cognitive decline

high-resolution 3D-T1

Intervention Type RADIATION

Subjects undergo a high-resolution 3D-T1 imaging to obtain structural images

diffusion tensor imaging (DTI)

Intervention Type RADIATION

Subjects undergo a DTI imaging to obtain images of white matter lesions

resting-state functional magnetic resonance imaging (rs-fMRI)

Intervention Type RADIATION

Subjects undergo rs-fMRI to investigate the differences in intra-regional brain activity and inter-regional functional connectivity

arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI)

Intervention Type RADIATION

Subjects undergo arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) to clarify the difference of cerebral blood flow (CBF) perfusion in certain regions

susceptibility-weighted images (SWIs)

Intervention Type RADIATION

Subjects undergo susceptibility-weighted images (SWIs) to segment the vein network

CVOD-WOS

Cerebral Venous Outflow Disturbance without symptoms such as tinnitus cerebri，somnipathy ，anxiety ，depression and cognitive decline

high-resolution 3D-T1

Intervention Type RADIATION

Subjects undergo a high-resolution 3D-T1 imaging to obtain structural images

diffusion tensor imaging (DTI)

Intervention Type RADIATION

Subjects undergo a DTI imaging to obtain images of white matter lesions

resting-state functional magnetic resonance imaging (rs-fMRI)

Intervention Type RADIATION

Subjects undergo rs-fMRI to investigate the differences in intra-regional brain activity and inter-regional functional connectivity

arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI)

Intervention Type RADIATION

Subjects undergo arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) to clarify the difference of cerebral blood flow (CBF) perfusion in certain regions

susceptibility-weighted images (SWIs)

Intervention Type RADIATION

Subjects undergo susceptibility-weighted images (SWIs) to segment the vein network

HC

Healthy control

high-resolution 3D-T1

Intervention Type RADIATION

Subjects undergo a high-resolution 3D-T1 imaging to obtain structural images

diffusion tensor imaging (DTI)

Intervention Type RADIATION

Subjects undergo a DTI imaging to obtain images of white matter lesions

resting-state functional magnetic resonance imaging (rs-fMRI)

Intervention Type RADIATION

Subjects undergo rs-fMRI to investigate the differences in intra-regional brain activity and inter-regional functional connectivity

arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI)

Intervention Type RADIATION

Subjects undergo arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) to clarify the difference of cerebral blood flow (CBF) perfusion in certain regions

susceptibility-weighted images (SWIs)

Intervention Type RADIATION

Subjects undergo susceptibility-weighted images (SWIs) to segment the vein network

Interventions

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high-resolution 3D-T1

Subjects undergo a high-resolution 3D-T1 imaging to obtain structural images

Intervention Type RADIATION

diffusion tensor imaging (DTI)

Subjects undergo a DTI imaging to obtain images of white matter lesions

Intervention Type RADIATION

resting-state functional magnetic resonance imaging (rs-fMRI)

Subjects undergo rs-fMRI to investigate the differences in intra-regional brain activity and inter-regional functional connectivity

Intervention Type RADIATION

arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI)

Subjects undergo arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) to clarify the difference of cerebral blood flow (CBF) perfusion in certain regions

Intervention Type RADIATION

susceptibility-weighted images (SWIs)

Subjects undergo susceptibility-weighted images (SWIs) to segment the vein network

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Cerebral venous outflow disturbance( moderate to severe stenosis in cerebral venous sinus or intracranial jugular veins ) is confirmed by two of magnetic resonance venography (MRV), computed tomography venography (CTV) or digital subtraction angiography (DSA)
* Accompanying symptoms such as tinnitus cerebri, cognitive decline, anxiety depression, sleep disorders, etc. for more than 6 months

Exclusion Criteria

* ear primary disease medicine related intracranial hypertension; Systemic disease of abnormal metabolism or inflammation; moderate to severe stenosis in intracranial, carotid or vertebral arteries; intracranial lesions.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes