Optimization Strategy of Carotid Artery Stenosis

NCT ID: NCT05629000

Last Updated: 2022-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-01-01

Study Completion Date

2026-12-31

Brief Summary

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The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy.

The main questions it aims to answer are:

* Identify best strategy that use multi-modal MRI and CT to assess patients' cerebral lesions and perfusion.
* Identify best strategy that use multi-modal MRI, PET-MRI ultrasound and CT to assess components and characters of patients' carotid plaques.

Participants will accept imaging examination before and after surgery. And doctors will collect basic characteristics, imaging results and biological samples of patients for analysis.

Detailed Description

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Conditions

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Carotid Artery Stenosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Carotid artery stenosis

patient with carotid artery stenosis

Carotid revascularization

Intervention Type PROCEDURE

All patients received carotid revascularization surgery at Peking Union Medical College Hospital.

MRI-PWI

Intervention Type DIAGNOSTIC_TEST

Multi-modal MRI before and after surgery.

CTA

Intervention Type DIAGNOSTIC_TEST

CTA before and after surgery.

PET/MRI

Intervention Type DIAGNOSTIC_TEST

PET/MRI before surgery.

Ultrasound

Intervention Type DIAGNOSTIC_TEST

Ultrasound before and after surgery.

Interventions

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Carotid revascularization

All patients received carotid revascularization surgery at Peking Union Medical College Hospital.

Intervention Type PROCEDURE

MRI-PWI

Multi-modal MRI before and after surgery.

Intervention Type DIAGNOSTIC_TEST

CTA

CTA before and after surgery.

Intervention Type DIAGNOSTIC_TEST

PET/MRI

PET/MRI before surgery.

Intervention Type DIAGNOSTIC_TEST

Ultrasound

Ultrasound before and after surgery.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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carotid endarterectomy and carotid artery stent

Eligibility Criteria

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Inclusion Criteria

1. patients with severe stenosis (≥50%) or near-occlusion diagnosed by computed tomographic angiogram;
2. patients received carotid endarterectomy at Peking Union Medical College Hospital

Exclusion Criteria

(1) Any contraindication to image examination; (3) refuse to sign the Informed consent.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Peking Union Medical College Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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vascular surgery department of PUMCH

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Zhichao Lai, MD

Role: CONTACT

01069152500

Facility Contacts

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Zhichao Lai, MD

Role: primary

01069152500

References

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Lai Z, Wang C, Liu X, Sun H, Guo Z, Shao J, Li K, Chen J, Wang J, Lei X, Shu K, Feng Y, Kong D, Sun W, Liu B. Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry. J Transl Med. 2024 Mar 7;22(1):247. doi: 10.1186/s12967-023-04723-1.

Reference Type DERIVED
PMID: 38454421 (View on PubMed)

Other Identifiers

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PUMCH-CAS-006

Identifier Type: -

Identifier Source: org_study_id

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