Analysis of Lipid Profiles in Samples Sperm and Seminal Plasma Under Artificial Insemination

NCT ID: NCT02704936

Last Updated: 2021-09-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2015-12-31

Study Completion Date

2018-10-31

Brief Summary

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Identify, by Lipidomics approaches, biochemical markers of fertility / infertility in sperm and seminal plasma linking the success or failure of the artificial insemination (IUI)

Detailed Description

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Analyze lipid profiles in samples of sperm and seminal plasma of three populations:

1. male sperm donors
2. men assigned to a program of assisted reproduction with normal sperm / slightly abnormal successfully in the IUI;
3. attached to a program of assisted reproduction with male semen Normal / slightly abnormal unsuccessfully in IUI

Establish partnerships between the composition of fatty acids, especially fatty acids polyunsaturated (PUFA) of the omega-3 (w3) series of samples analyzed parameterssemen and results of the IA to identify biochemical markers of fertility.

Assess markers found by checking the increase in the rate of success in the IA.

Conditions

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Primary Infertility

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Male donor

42 samples of semen from male donor attached to a donation program Normal sperm count as WHO 2010.

No interventions assigned to this group

IUI positive pregnancy

42 samples of semen from a program attached to patients for insemination Male indication Normal / slightly abnormal sperm count or infertility source unknown and have obtained positive pregnancy in any of the first 4 treatments IUI

No interventions assigned to this group

IUI unsuccessful pregnancy

42 samples of semen from a program attached to patients for insemination Male indication Normal / slightly abnormal sperm count or infertility source unknown and after undergoing maximum 4 cycles have unsuccessfully IUI indication of IVF / ICSI.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Fallopian unobstructed Men donor group
* Appear as sperm donor
* Age between 18-35 years
* Sexual abstinence 3-5 days

Exclusion Criteria

* Uterine malformations (fibroids, adenomyosis, uterine malformations or acquired congenital) and fallopian tubes (tubal occlusion)
* Obesity BMI (Body Mass Index)\> 30 kg / m2
* Presence of altered tubal toxic habits (smoking\> 15 cigarettes per day, alcohol or drug abuse).


* ≤ 38 years
* Natural cycles and stimulated
* The criteria inclusion / exclusion group A
* Time sterility not exceeding three years.
Minimum Eligible Age

18 Years

Maximum Eligible Age

38 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of the Basque Country (UPV/EHU)

OTHER

Sponsor Role collaborator

IVI Bilbao

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marcos Ferrando, MD

Role: PRINCIPAL_INVESTIGATOR

IVI Bilbao

Locations

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IVI Bilbao

Leioa, Vizcaya, Spain

Site Status

Countries

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Spain

Other Identifiers

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505-BIO-035-MF

Identifier Type: -

Identifier Source: org_study_id

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