Effect of Cervical Occlusion During Intrauterine Insemination (IUI)

NCT ID: NCT00951171

Last Updated: 2012-08-28

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

93 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-02-28

Study Completion Date

2011-12-31

Brief Summary

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Study Hypothesis: There is a difference in pregnancy rates between intrauterine insemination (IUI) in cycles performed with cervical occlusion by a balloon catheter designed for sonohysterograms as compared to those performed with a standard inseminator.

The investigators will compare pregnancy rates in patients undergoing routine IUI either with balloon occlusion or with standard insemination. The patients will receive the standard clinical care per the investigators' office guidelines, except they will be randomized to insemination with either of two catheters.

Detailed Description

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An open speculum will be used and patients will undergo insemination with their partners sperm (same quantity in both arms). If randomized to treatment arm a balloon catheter will be filled with 1cc of air prior to insemination. The speculum will be removed immediately and the catheter will be left in for 15 minutes and then removed. Pregnancy outcomes will be recorded in both groups.

Conditions

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Infertility

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Cervical occulsion

Insemination Eliptosphere catheter filled with 1cc of air for 15 minutes. H/S Eliptosphere by Copper surgical (U.S. Patent No. 5,624,399)

Group Type EXPERIMENTAL

Intrauterine Insemination

Intervention Type PROCEDURE

The intervention arm will undergo temporary (15 minutes) cervical occlusion with the eliptosphere intracervical catheter. This catheter is typically used to perform saline infusion ultrasounds to image the uterine cavity in our practice.

Standard IUI

Insemination with TOmcat catheter

Group Type ACTIVE_COMPARATOR

IUI with the standard inseminator

Intervention Type PROCEDURE

The control arm will undergo insemination with the standard inseminator (TOmcat catheter).

Interventions

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Intrauterine Insemination

The intervention arm will undergo temporary (15 minutes) cervical occlusion with the eliptosphere intracervical catheter. This catheter is typically used to perform saline infusion ultrasounds to image the uterine cavity in our practice.

Intervention Type PROCEDURE

IUI with the standard inseminator

The control arm will undergo insemination with the standard inseminator (TOmcat catheter).

Intervention Type PROCEDURE

Other Intervention Names

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H/SH

Eligibility Criteria

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Inclusion Criteria

* All patients undergoing IUI for unexplained infertility in our office: Center for Reproduction and Infertility (Providence, RI)

Exclusion Criteria

* "Abnormal" Semenalysis TMC \< 5 million
* Blocked Fallopian tubes
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Women and Infants Hospital of Rhode Island

OTHER

Sponsor Role lead

Responsible Party

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Andrew Blazar, M.D.

Prinicpal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andrew Blazar, MD

Role: PRINCIPAL_INVESTIGATOR

Women & Infants Hospital

Locations

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Center for Reproduction and Infertility

Providence, Rhode Island, United States

Site Status

Countries

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United States

Other Identifiers

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CO_IUI

Identifier Type: -

Identifier Source: org_study_id