Maternal and Fetal Compatibility in Assisted Reproductive Technology (ART)-Oocyte Donor Influences Live Birth Rate

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2022-08-01

Brief Summary

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Has the maternal KIR haplotype an impact in pregnancy, miscarriage and live birth rates per embryo transfer in donor oocytes -ART by paternal and oocyte donor HLA-C?

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Detailed Description

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The combination of maternal KIR haplotype and parental, donors HLA-C, could predict which couple can benefit for the selection of single embryo transfer (SET)/double embryo transfer (DET), or donor selection by HLA-C in ART, in order to increase the live birth rate (LBR)/cycle since HLA-C1/C1 donors are predicted to be safer and C2/C2 males or oocyte donors may be mor "dangerous" as identified by epidemiological studies

Conditions

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Infertility

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Receiver patients in donor oocyte -ART

Maternal and fetal compatibility KIR HLA-C determinations in ART -oocyte donor

KIR HLAC determinations

Intervention Type GENETIC

We will take blood samples for KIR HLA-C determinations.

Interventions

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KIR HLAC determinations

We will take blood samples for KIR HLA-C determinations.

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* BMI between 19 - 27 kg/m2
* Blastocyst embryo transfer previous.
* Normal karyotype, thrombophylic and immunological results.
* Normal clinical history, viral serology, hormonal analysis (TSH, T4, prolactin, estrogen, progesterone), spermiogram, sperm FISH and pelvic ultrasound results.

Exclusion Criteria

* Pregnancy women.
* Psychiatric disorders.
* Uterus alterations.
* Polycystic ovary syndrome
* Genetic and autoimmune diseases.
* Infectious diseases.
* Corticoid and immunosuppressant treatments previous.

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes