Cumulative Live Birth Rates in Patients With Repeated Implantation Failure (RIF) Undergoing Preimplantation Genetic Screening (PGS )
NCT ID: NCT03001648
Last Updated: 2016-12-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
80 participants
OBSERVATIONAL
2014-01-31
2016-12-31
Brief Summary
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Patients scheduled for PGS underwent one or more stimulation cycles (oocyte or blastocyst banking) in order to maximize chances of embryo transfer. PGS cycles are analyzed globally. Aditionally, PGS cycles with a single stimulation cycle are analyzed in comparison to standard IVF cycles.
Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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PGS
Patients with RIF scheduled for PGS (Preimplantation Genetic Screening) with trophectoderm biopsy using arrays comparative genomic hybridation (aCGH) underwent one or more stimulation cycles. If euploid blastocysts were available, patients underwent frozen embryo transfer/s.
PGS (Preimplantation Genetic Screening) with trophectoderm biopsy
PGS (Preimplantation Genetic Screening) with trophectoderm biopsy using arrays comparative genomic hybridizatioon (aCGH)
Standard IVF
Patients with RIF scheduled for standard IVF (In Vitro Fertilization) underwent a single stimulation cycle with the fresh embryo transfer and the subsequent frozen embryo transfers if there were surplus frozen embryos and the fresh embryo transfer was unsuccessful.
No interventions assigned to this group
Interventions
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PGS (Preimplantation Genetic Screening) with trophectoderm biopsy
PGS (Preimplantation Genetic Screening) with trophectoderm biopsy using arrays comparative genomic hybridizatioon (aCGH)
Eligibility Criteria
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Inclusion Criteria
* repeated implantation failure: at least 4 day 3 good quality embryos or 2 good quality blastocysts transferred without implantation
Exclusion Criteria
* presence of uni or bilateral hydrosalpinx, uterine malformation, thrombophilia, uncontrolled thyroid disfunction or autoimmune disease
18 Years
38 Years
FEMALE
No
Sponsors
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Fundacion Dexeus
OTHER
Responsible Party
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Marta Devesa
Staff member of Reproductive Unit
Locations
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Departamento de Ginecología Obstetricia y Reproducción. Hospital Universitari Dexeus
Barcelona, Barcelona, Spain
Countries
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Other Identifiers
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SMD-DEX-2016-02
Identifier Type: -
Identifier Source: org_study_id