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Lymphocyte Count as a Sign of Immunoparalysis and Its Correlation With Nutritional Status in Septic Pediatric Patients

NCT ID: NCT02698683

Last Updated: 2016-03-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

14 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-02-28

Study Completion Date

2016-01-31

Brief Summary

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Participants were classified as normal or malnourished according to anthropometric measures. Serum albumin and zinc were recovered on the 1st and 7th days of hospitalization. Lymphocyte count was also recorded on the 1st and 7th days.

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Detailed Description

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The investigators enrolled 14 consecutive patients with sepsis. Patients were classified as normal or malnourished according to anthropometric measures. As an additional evaluation of nutritional status, serum albumin and zinc were recovered on the 1st and 7th days of hospitalization. Lymphocyte count was also recorded on the 1st and 7th days. Investigators correlated nutritional status with lymphocyte count and zinc dosage.

Conditions

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Lymphopenia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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malnourished

low zinc, low albumin, anthropometric measures lower than percentile 5 lymphocyte count

lymphocyte count

Intervention Type OTHER

lymphocyte count

well nourished

normal zinc, normal albumin, anthropometric measures higher than percentile 5 lymphocyte count

lymphocyte count

Intervention Type OTHER

lymphocyte count

Interventions

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lymphocyte count

lymphocyte count

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* septic patients

Exclusion Criteria

\-
Minimum Eligible Age

1 Month

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Sao Paulo

OTHER

Sponsor Role lead

Responsible Party

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Talita Freitas Manzoli

Medical doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Delgado AF, Okay TS, Leone C, Nichols B, Del Negro GM, Vaz FA. Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit. Clinics (Sao Paulo). 2008 Jun;63(3):357-62. doi: 10.1590/s1807-59322008000300012.

Reference Type RESULT
PMID: 18568246 (View on PubMed)

Manzoli TF, Delgado AF, Troster EJ, de Carvalho WB, Antunes AC, Marques DM, Zamberlan P. Lymphocyte count as a sign of immunoparalysis and its correlation with nutritional status in pediatric intensive care patients with sepsis: A pilot study. Clinics (Sao Paulo). 2016 Nov 1;71(11):644-649. doi: 10.6061/clinics/2016(11)05.

Reference Type DERIVED
PMID: 27982165 (View on PubMed)

Other Identifiers

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2015-LCSINS

Identifier Type: -

Identifier Source: org_study_id

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