Sensitivity and Specificity of Leucocytes Subpopulation Versus Platelet Indices in Prediction of Clinical Outcome for Candidates With Sepsis. A Bi-centric Observational Clinical Trial

NCT ID: NCT06612307

Last Updated: 2024-09-25

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 161 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-09-25
• Study Completion Date: 2025-08-20

Brief Summary

Leucocyte subpopulation and platelet indices analysis can predict clinical outcome

Conditions

Sepsis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Adult population of both sex, aged 20 or older admitted to the ICU with a diagnosis of sepsis were screened for inclusion within 48 h of presentation to the hospital. Sepsis was defined as per the Sepsis-3 definition, 6 ie, the presence of suspected or documented infection with organ dysfunction determined by an acute increase of sequential organ failure assessment (SOFA) score by 2 or more points

Exclusion Criteria

• Patient refusal.
• History of surgery in the last 7 days from admission.
• Immunocompromised population ( post-transplantation, steroid use > 5 mg per day, malignancy, HIV, on chemotherapy).
• Population with history of thrombocytopenia ( ITP, aplastic anemia, drug induced)
• History of thrombocytosis ( idiopathic thrombocytosis, post-splenectomy)
• History of platelet transfusion one week before admission.
• Bone marrow transplanted population .
• Chronic liver and kidney disease.
• Von-Willebrand disease.
• Patients on antiplatelet therapy ( Aspirin, clopidogrel).
• Thrombocytopenic population ( ITP, TTP,HELLP) .
• Myelodysplastic or proliferative patients.
• Blood dyscarsiasis
• Obestetric parturients.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Minia University

OTHER

Sponsor Role: lead

Responsible Party

Mina Maher

Ass professor anesthesia and pain

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

Anet 19-2

Identifier Type: -

Identifier Source: org_study_id