Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

290 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-20

Study Completion Date

2026-03-19

Brief Summary

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This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.

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Detailed Description

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Sepsis affects more than 30 million people annually worldwide and is one of the significant causes of death in critical patients worldwide. Any infected person can potentially develop sepsis, and the incidence of sepsis is as high as 1-2% of all hospitalized patients.

Many potential sepsis biomarkers have been proposed, procalcitonin (PCT) and C-reactive protein (CRP) being the most frequently studied.

The ratio of neutrophils to lymphocytes and platelets (N/LP) is a low-cost measure that can be obtained through routine blood tests and is often used to reflect the body's inflammatory state.

Conditions

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Neutrophils to Lymphocytes Platelets Procalcitonin Total Leucocytic Count Prognostic Outcome Septic Patients Intensive Care Unit

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Study group

Septic patients (under the third international consensus definitions of sepsis and septic shock)

Neutrophils to Lymphocytes and Platelets ratio (N/LP)

Intervention Type DIAGNOSTIC_TEST

The Neutrophils to Lymphocytes and Platelets ratio (N/LP) will be measured

Interventions

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Neutrophils to Lymphocytes and Platelets ratio (N/LP)

The Neutrophils to Lymphocytes and Platelets ratio (N/LP) will be measured

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Age from 18 to 70 years old.
* Both sexes.
* Septic patients (under the third international consensus definitions of sepsis and septic shock).

Exclusion Criteria

* Pregnancy
* Malignancy
* On immunosuppressive therapy
* Hematological Disorders
* Major Trauma
* Major Burns
* Child-Pugh Class C Liver Cirrhosis
* On Hemodialysis

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No