OCEAN Registry: Obesity and Clock for Elegant Aging Registry

NCT ID: NCT02674230

Last Updated: 2024-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-07-31

Study Completion Date

2026-06-30

Brief Summary

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This study aims to study the relationships between obesity, circadian rhythm, and aging. The investigators set up a prospective cohort registry for morbid obesity, obesity, and normal subjects with annual follow-up. The cohort aims to investigate the pathophysiological, molecular, genetic, and cellular aspects of the relationships between obesity, circadian deregulation, and impacts on aging. Clinical data, questionnaires, biological material, and molecular signatures will be collected and investigated.

Detailed Description

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The objective of this observational study is the follow-up of 2000 adult obesity (BMI ≥ 35 and 24-35 kg/m2) and non-obese subjects with annual follow-up for 10 years. Clinical data, biochemistry, and biological samples (serum, DNA, RNA, white blood cells) will be collected and stored. Adipose tissues will be collected if participants received liposuction, plastic surgery, bariatric surgery, dermatological procedure, intra-abdominal operation, and cardiovascular surgery. Questionnaires will be obtained with special nurse including sleep quality, chronotypes, and circadian activities. During follow up period, major adverse cardiovascular events will be monitored.

The investigators anticipate that the results generated from the study will provide valuable data to a better understanding of the relationships between obesity, circadian rhythm, and aging.

Conditions

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Obesity Circadian Dysregulation Aging Cardiovascular Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Extreme obesity

BMI ≥35kg/m2

No interventions assigned to this group

Obesity

BMI 24-34.9kg/m2

No interventions assigned to this group

Normal subjects

BMI \<24kg/m2. No systemic disease, including hypertension, diabetes, liver cirrhosis, chronic kidney disease, and psychiatric disease.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 20 years old
* Body mass index ≥ 24 kg/m2
* For normal subjects, Body mass index \< 24 kg/m2

Exclusion Criteria

* No inform consent
* Use of steroid medications
* Severe systemic diseases or organ failure with estimated life expectancy of 6 months or less
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chang Gung Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Chao-Yung Wang

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Chao-Yung Wang, MD

Role: PRINCIPAL_INVESTIGATOR

Chang Gung Memorial Hospital

Locations

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Chang Gung Memorial Hospital

Taoyuan District, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Chao-Yung Wang, MD

Role: CONTACT

886-3-3281200 ext. 8750

Facility Contacts

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Chao-Yung Wang, MD

Role: primary

886-3-3281200 ext. 8750

Other Identifiers

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100-0250A3

Identifier Type: -

Identifier Source: org_study_id

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