Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
150 participants
OBSERVATIONAL
2022-01-01
2025-12-31
Brief Summary
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Detailed Description
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120 patients with obesity and 30 healthy individuals with normal BMI were enrolled.
All patients with obesity underwent LSG. A multidisciplinary team evaluated participants with obesity at baseline, 1, 3, 6, and 12 months after laparoscopic sleeve gastrectomy (LSG). Anthropometrics, Metabolic indicators, sex hormones, menstruation，glucose-lipid metabolic markers, and hepatic steatosis assessed by FibroScan(CAP value and E value) were measured baseline and postoperative. Resting and task state functional magnetic resonance imaging (fMRI) measurements were performed at baseline for all participants at two-time points before and after meals. Measurements were repeated in obese patients 6 months after surgery.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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MHO group
Metabolic healthy obesity
Laparoscopic sleeve gastrectomy
Obese patients of different subtypes were all expected to undergo bariatric surgery
HMO-U group
Hypermetabolic obesity-hyperuricemia
Laparoscopic sleeve gastrectomy
Obese patients of different subtypes were all expected to undergo bariatric surgery
HMO-I group
Hypermetabolic obesity-hyperinsulinemia
Laparoscopic sleeve gastrectomy
Obese patients of different subtypes were all expected to undergo bariatric surgery
LMO group
Hypometabolic obesity
Laparoscopic sleeve gastrectomy
Obese patients of different subtypes were all expected to undergo bariatric surgery
control group
Healthy person
No interventions assigned to this group
Interventions
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Laparoscopic sleeve gastrectomy
Obese patients of different subtypes were all expected to undergo bariatric surgery
Eligibility Criteria
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Inclusion Criteria
* BMI over 37.5kg/m2, or BMI over 32.5kg/m2 with diabetes which meets the recommended cut-off bariatric surgery of the Guidelines for surgical treatment of obesity accompanied with or without type 2 diabetes in China.
Exclusion Criteria
* pregnancy or location
* contraindications for laparoscopic surgery, such as gastrointestinal diseases of intra-abdominal infection, adhesion, etc
* severe heart, liver, and kidney dysfunction
* organic and systemic diseases intolerant of surgery.
18 Years
65 Years
ALL
Yes
Sponsors
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Shanghai 10th People's Hospital
OTHER
Responsible Party
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Shen Qu
Clinical Professor and Principal Investigator
Principal Investigators
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Shen Qu, Dr.
Role: STUDY_CHAIR
Shanghai 10th People's Hospital
Locations
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Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Brain function in obesity
Identifier Type: -
Identifier Source: org_study_id
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