Cognitive Assessment and Brain Function Evaluation in Patients With Non-alcoholic Fatty Liver Disease
NCT ID: NCT05563259
Last Updated: 2024-06-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
500 participants
OBSERVATIONAL
2020-05-01
2025-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Groups/Cohorts Interventions Control
patients with steatosis \< 5%
Cognitive assessment, functional magnetic resonance imaging
Our study investigated cognitive function, MRI measures of brain structure and activation in patients undergoing liver biopsy. We aimed to evaluate the changes of cognition during the process of NAFLD and explore the association between brain alterations and cognition.
non-NASH
patients with steatosis ≥ 5% and did not achieve the criteria for NASH
Cognitive assessment, functional magnetic resonance imaging
Our study investigated cognitive function, MRI measures of brain structure and activation in patients undergoing liver biopsy. We aimed to evaluate the changes of cognition during the process of NAFLD and explore the association between brain alterations and cognition.
NASH
patients with NAFLD Activity Score (NAS) ≥ 5
Cognitive assessment, functional magnetic resonance imaging
Our study investigated cognitive function, MRI measures of brain structure and activation in patients undergoing liver biopsy. We aimed to evaluate the changes of cognition during the process of NAFLD and explore the association between brain alterations and cognition.
Interventions
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Cognitive assessment, functional magnetic resonance imaging
Our study investigated cognitive function, MRI measures of brain structure and activation in patients undergoing liver biopsy. We aimed to evaluate the changes of cognition during the process of NAFLD and explore the association between brain alterations and cognition.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* right handed
Exclusion Criteria
* with history of other liver diseases including chronic hepatitis, biliary obstructive diseases or autoimmune hepatitis
* with thyroid diseases
* in a state of anxiety or depression
* inability to complete cognitive function scales
20 Years
75 Years
ALL
Yes
Sponsors
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Yan Bi
OTHER
Responsible Party
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Yan Bi
Chief Physician
Locations
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at Division of Endocrinology, the Affiliated Drum Tower Hospital of Nanjing University
Nanjing, Jiangsu, China
Countries
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Other Identifiers
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NAFLDCOG
Identifier Type: -
Identifier Source: org_study_id
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