Exploration of Gender Differences in Liver Aging

NCT ID: NCT06591897

Last Updated: 2024-10-08

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 18 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-09-27
• Study Completion Date: 2027-09-20

Brief Summary

The liver is an important metabolic organ in the body. It participates in central metabolic activities to maintain systemic homeostasis. It is also one of the most vulnerable organs in the process of individual aging. During aging, the volume, blood flow, metabolic capacity and regenerative capacity of the liver decrease. Liver function changes with age can lead to age-related systemic susceptibility diseases.

Therefore, understanding the changes of metabolism and immune function in the process of liver aging and studying the regulation mechanism of liver aging will provide an important reference for understanding the causes of increased susceptibility to liver-related diseases in the elderly population.On the other hand, gender factors also affect organ function, leading to differences in human aging and disease outcomes.At present, the omics research on liver aging is mainly based on tissue-level transcription, protein or metabolomics, and most of the conclusions are focused on hepatocytes. However, for other cell types and microenvironment interactions, people know little about the aging changes at the cellular levelBased on the current research status, this study aims to explore the gender differences in the process of liver aging, using emerging technologies such as the combination of single-cell multi-omics and spatial localization, to reveal the factors driving liver aging from a gender perspective, and to promote the development of accurate interventions for aging and aging-related diseases.

Conditions

Healthy Population

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Liver function indicators are in the normal reference range.
• Liver imaging examination showed normal.

Exclusion Criteria

• Patients with previous liver-related diseases.
• Subjects with important organ dysfunction / failure or other serious diseases ( myocardial infarction, malignant tumor, severe neurological or psychiatric history, severe infection, coagulation dysfunction, etc. )
• Moderate malnutrition ( BMI < 17kg / m2 ) and severe anemia ( Hb < 60g / L ).
• Subjects and their families who disagreed with the study protocol.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

daren Liu, MD, PhD

Role: STUDY_DIRECTOR

Zhejiang University

Locations

2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

Hangzhou, Zhejiang, China

Site Status: RECRUITING

Countries

China

Central Contacts

daren Liu, MD, PhD

Role: CONTACT

darenliu@zju.edu.cn

15968179036

Facility Contacts

Liu Daren, MD, PhD

Role: primary

darenliu@zju.edu.cn

+86-15968179036

Other Identifiers

2024-0815

Identifier Type: -

Identifier Source: org_study_id