Endotracheal Intubation Among the Critically Ill: HEMAIR Pilot Study
NCT ID: NCT02508948
Last Updated: 2020-01-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
1288 participants
OBSERVATIONAL
2015-08-31
2019-12-31
Brief Summary
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Detailed Description
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Aim 2: To derive and validate a prediction model for hemodynamic compromise, i.e., post-intubation hypotension \[defined as a decrease at any point in mean arterial pressure less than 65 mmHg; systolic blood pressure less than 80 mm Hg and/or a reduction in systolic blood pressure of 40% from baseline; or the initiation of, or increase in infusion dosage of, any vasopressor medication (bolus or infusion) during the 30 minute period following intubation\] \[38-39\].
Aim3: To derive and validate a predication model for hypoxemia (decrease in pulse oximetry to oxygen saturation less than 88% during the procedure).
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Surgical and medical intensive care unit adult patients
* Adult patients requiring endotracheal intubation during the time period of study
Exclusion Criteria
* Endotracheal intubations performed outside the ICU (in the operating room, in and outside the hospital) are excluded
18 Years
ALL
No
Sponsors
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Berkshire Medical Center
OTHER
Bridgeport Hospital
OTHER
Detroit Medical Center
OTHER
Geisinger Clinic
OTHER
Marshfield Clinic
UNKNOWN
Memorial Medical Center
OTHER
Mercy Hospital
UNKNOWN
University of North Carolina
OTHER
Johns Hopkins University
OTHER
University of Kentucky
OTHER
The Cleveland Clinic
OTHER
Wake Forest University Health Sciences
OTHER
Corpus Christi Medical Center
UNKNOWN
University of Oklahoma
OTHER
Creighton University
OTHER
University of Southern California
OTHER
Essentia Health
OTHER
Mayo Clinic
OTHER
Responsible Party
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Nathan J. Smischney
PI
Principal Investigators
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Rahul Kashyap, MBBS
Role: STUDY_DIRECTOR
Mayo Clinic
Locations
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Mayo Clinic, Scottsdale
Scottsdale, Arizona, United States
University of South California
Los Angeles, California, United States
Memorial Medical Center
Modesto, California, United States
Bridgeport Hospital/Yale
Bridgeport, Connecticut, United States
Mayo Clinic, Jacksonville
Jacksonville, Florida, United States
University of Kentucky
Lexington, Kentucky, United States
Cynthia Callahan,Berkshire Medical Center
Pittsfield, Massachusetts, United States
Detroit Medical Center
Detroit, Michigan, United States
Mercy Hospital
St Louis, Missouri, United States
Creighton University
Omaha, Nebraska, United States
Cleveland Clinic
Cleveland, Ohio, United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
Geisinger Health System
Danville, Pennsylvania, United States
Corpus Christi Medical Center
Corpus Christi, Texas, United States
Marshfield Clinic
Marshfield, Wisconsin, United States
Arora Health Care
Milwaukee, Wisconsin, United States
Countries
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References
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Smischney NJ, Surani SR, Montgomery A, Franco PM, Callahan C, Demiralp G, Tedja R, Lee S, Kumar SI, Khanna AK. Hypotension Prediction Score for Endotracheal Intubation in Critically Ill Patients: A Post Hoc Analysis of the HEMAIR Study. J Intensive Care Med. 2022 Nov;37(11):1467-1479. doi: 10.1177/08850666221085256. Epub 2022 Mar 4.
Smischney NJ, Khanna AK, Brauer E, Morrow LE, Ofoma UR, Kaufman DA, Sen A, Venkata C, Morris P, Bansal V. Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study. J Intensive Care Med. 2021 Dec;36(12):1466-1474. doi: 10.1177/0885066620962445. Epub 2020 Oct 1.
Smischney NJ, Kashyap R, Khanna AK, Brauer E, Morrow LE, Seisa MO, Schroeder DR, Diedrich DA, Montgomery A, Franco PM, Ofoma UR, Kaufman DA, Sen A, Callahan C, Venkata C, Demiralp G, Tedja R, Lee S, Geube M, Kumar SI, Morris P, Bansal V, Surani S; SCCM Discovery (Critical Care Research Network of Critical Care Medicine) HEMAIR Investigators Consortium. Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study. PLoS One. 2020 Aug 31;15(8):e0233852. doi: 10.1371/journal.pone.0233852. eCollection 2020.
Smischney N, Kashyap R, Seisa M, Schroeder D, Diedrich D. Endotracheal Intubation Among the Critically Ill: Protocol for a Multicenter, Observational, Prospective Study. JMIR Res Protoc. 2018 Dec 7;7(12):e11101. doi: 10.2196/11101.
Related Links
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Mayo Clinic Clinical Trials
Other Identifiers
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15-002328
Identifier Type: -
Identifier Source: org_study_id
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