Sample Collection Study to Evaluate DNA Markers in Subjects With Inflammatory Bowel Disease (IBD)

NCT ID: NCT02503696

Last Updated: 2016-08-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

697 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-09-30

Study Completion Date

2016-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The primary objective of this study is to gather stool samples from subjects with inflammatory bowel disease (IBD) to be added to a test set of stool samples that will be utilized to help select molecular markers and determine the optimal sensitivity and specificity values for the Exact IBD-ACRN surveillance test for colorectal cancer (CRC).

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Inflammatory Bowel Disease Colorectal Neoplasms Digestive System Diseases Colonic Diseases Colorectal Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

IBD

Subjects will be men and women, 18-84 years of age, inclusive, who have been diagnosed with IBD. Each with a screening colonoscopy resulting in normal findings.

Stool Collection Kit

Intervention Type DEVICE

Stool Collection Kit.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Stool Collection Kit

Stool Collection Kit.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Male or Female 18 - 84 years of age, inclusive, who have been diagnosed with IBD.
* Willing to provide a stool sample ≤120 but ≥7 days after a surveillance colonoscopy, which was negative for cancer/dysplasia.
* Written informed consent document signed and dated by the subject.

Exclusion Criteria

* Any condition that in the opinion of the investigator should preclude participation in the study.
* A history of aerodigestive tract cancer.
* Prior colorectal resection, except ileocolic resection in Crohn's disease patients.
* IBD limited only to the rectum.
* Subject has participated in any clinical study within the previous 30 days wherein an investigational compound or device was, or may have been, introduced into the subject.
Minimum Eligible Age

18 Years

Maximum Eligible Age

84 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Exact Sciences Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Graham Lidgard, PhD

Role: STUDY_CHAIR

Exact Sciences

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Digestive Health Specialists of the Southeast

Dothan, Alabama, United States

Site Status

UC San Diego Medical Center

La Jolla, California, United States

Site Status

Facey Medical Foundation

Mission Hills, California, United States

Site Status

Medical Research Center of Conneticut

Hamden, Connecticut, United States

Site Status

Edward Hines Jr. VA Hospital

Hines, Illinois, United States

Site Status

Gastroenterology Associates, LLC

Baton Rouge, Louisiana, United States

Site Status

Delta Research Partners

Monroe, Louisiana, United States

Site Status

Louisiana Research Center, LLC

Shreveport, Louisiana, United States

Site Status

Metropolitan Gastroenterology Group, PC Chevy Chase Clinical Research

Chevy Chase, Maryland, United States

Site Status

Boston Medical Center

Boston, Massachusetts, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

HealthEast Midway Clinic

Saint Paul, Minnesota, United States

Site Status

Gastrointestinal Associates

Jackson, Mississippi, United States

Site Status

AGA Clinical Research Associates, LLC

Egg Harbor TWP, New Jersey, United States

Site Status

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Site Status

Asheville Gastroenterology Associates, PA

Asheville, North Carolina, United States

Site Status

University of North Carolina

Chapel Hill, North Carolina, United States

Site Status

Kinston Medical Specialists, PA

Kinston, North Carolina, United States

Site Status

Digestive Health Specialists, PA

Winston-Salem, North Carolina, United States

Site Status

UC Health

Cincinnati, Ohio, United States

Site Status

Cleveland Clinic

Cleveland, Ohio, United States

Site Status

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Site Status

Charlottesville Medical Research Center, LLC

Charlottesville, Virginia, United States

Site Status

Gastroenterology Associates of Tidewater

Chesapeake, Virginia, United States

Site Status

Blue Ridge Medical Research

Lynchburg, Virginia, United States

Site Status

University of Wisconsin Hospital & Clinics

Madison, Wisconsin, United States

Site Status

Wisconsin Center for Advanced Research

Milwaukee, Wisconsin, United States

Site Status

University of Calgary - Division of Gastroenterology

Calgary, Alberta, Canada

Site Status

Winnipeg Regional Health Authority- Health Sciences

Winnipeg, Manitoba, Canada

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Canada

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2014-05

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

IBD Neoplasia Surveillance RCT
NCT05809999 RECRUITING NA
Stool Sample Collection Study
NCT06294873 RECRUITING