The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency Department

NCT ID: NCT02463669

Last Updated: 2020-10-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-30

Study Completion Date

2020-10-04

Brief Summary

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The purpose of this study is to determine if splenomegaly on point-of-care ultrasound (POCUS) is an accurate and user-friendly surrogate to the heterophile antibody test and Epstein-Barr Virus (EBV) serologies to diagnose acute mononucleosis infection in patients presenting with sore throat to the Emergency Department (ED).

Detailed Description

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The investigators seek to determine whether the presence of splenomegaly on POCUS can accurately diagnose acute infectious mononucleosis in symptomatic ED patients, and determine the feasibility of performing point-of-care ultrasound for splenomegaly by emergency physicians in the emergency department setting.

Conditions

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Infectious Mononucleosis Splenomegaly

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Point-of-care ultrasound

Enrolled patients will undergo POCUS of the spleen by the treating emergency physician (resident, fellow or attending). Canadian Emergency Ultrasound Society (CEUS) certified residents, fellows and attending physicians will conduct the bedside ultrasonography after receiving specific training for the purposes of this study. The spleen will be assessed using a curved 2-6 Megahertz (MHz) transducer with the participant in the supine position. The cranio-caudal splenic length will be measured and its maximum dimension will be recorded on the standardized study data sheet.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients aged between 10 and 35 year-old presenting to the ED with suspected acute infectious mononucleosis

Exclusion Criteria

* Chronic infectious disorders (eg. tuberculosis, malaria, HIV, syphilis)
* Inflammatory disorders (eg. sarcoidosis, amyloidosis, systemic lupus erythematosus, Felty syndrome)
* Proliferative disorders (eg. lymphoma, leukemia, essential thrombocytopenia, polycythemia vera)
* Congestive disorders (eg: cirrhosis, portal hypertension, right heart failure, congenital heart disease)
* Chronic haemolytic anemia (eg. sickle cell, thalassemia, hereditary spherocytosis)
* Storage diseases (eg. Gaucher, Niemann-Pick)
* Splenectomy
* Inability to give informed consent
Minimum Eligible Age

10 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Jewish General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Laurie Robichaud

Laurie Robichaud, MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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CHU Sainte-Justine

Montreal, Quebec, Canada

Site Status

Jewish General Hospital

Montreal, Quebec, Canada

Site Status

Countries

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Canada

Other Identifiers

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POCUSIM01

Identifier Type: -

Identifier Source: org_study_id

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