Exercise Genes: Genomic Association With Exercise Reinforcement

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

88 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-30

Study Completion Date

2015-12-31

Brief Summary

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This study tests whether different physical activity patterns are linked an individual's genes.

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Detailed Description

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The investigators propose that an individual's genetics are one factor that may be associated with the motivating aspect or attractiveness of exercise and therefore the choice to exercise rather than be sedentary. They propose to study the association of the genomic signatures with the reinforcing (motivating) value of different types of exercise. This has never been investigated and may uncover underlying mechanisms that would help to understand individual differences in exercise motivation. The ultimate impact of this work is a greater number of Americans being physically active, meeting the United States Department of Agriculture (USDA) dietary guidelines for physical activity, and maintaining a healthy body weight. This study will be funded and undertaken at the Grand Forks Human Nutrition Research Center (GFHNRC). The purpose will be to assess genetic underpinnings of the motivating value of resistance and aerobic exercise, and to determine whether the motivating value of aerobic and resistance exercise are associated with usual participation in these modes of exercise.

Conditions

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Overweight Obesity Physical Activity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Aerobic Exercise vs Sedentary Option

Relative Reinforcing Value of aerobic exercise versus sedentary activity will be determined.

Group Type OTHER

Aerobic Exercise

Intervention Type OTHER

Subjects will sample and rate their liking of three cardiovascular machines (treadmill, cycle ergometer, elliptical step ergometer) to determine which one will be used during the test.

Sedentary Option

Intervention Type OTHER

Subjects will rate their liking of three sedentary activities (reading magazines, playing puzzles, completing word games) as an alternative to exercise.

Resistance Exercise vs Sedentary Option

Relative Reinforcing Value of resistance exercise versus sedentary activity will be determined.

Group Type OTHER

Resistance Exercise

Intervention Type OTHER

Subjects will sample and rate their liking of three different resistance training circuits (upper body, lower body, core) to determine which one will be used during the test.

Sedentary Option

Intervention Type OTHER

Subjects will rate their liking of three sedentary activities (reading magazines, playing puzzles, completing word games) as an alternative to exercise.

Interventions

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Aerobic Exercise

Subjects will sample and rate their liking of three cardiovascular machines (treadmill, cycle ergometer, elliptical step ergometer) to determine which one will be used during the test.

Intervention Type OTHER

Resistance Exercise

Subjects will sample and rate their liking of three different resistance training circuits (upper body, lower body, core) to determine which one will be used during the test.

Intervention Type OTHER

Sedentary Option

Subjects will rate their liking of three sedentary activities (reading magazines, playing puzzles, completing word games) as an alternative to exercise.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI within 18.5-35.0 kg/m2
* Healthy enough to exercise
* Active or inactive (not exercising at this time)

Exclusion Criteria

* Taking any drugs that affect energy expenditure (e.g., thyroid, glucose-lowering drugs)
* Have gained or lost more than 5% of body weight over the past 6 months
* Use tobacco
* Pregnant or lactating or plan to become pregnant in the next 6 months
* Have any health conditions that prevent the individual from safely exercising (e.g., cardiovascular, liver, endocrine, or pulmonary diseases)

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes