Characterization of Obesity-related Cardiomyopathy Through Exploration of Human Atrial Trabeculae Contraction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

134 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-06-03

Study Completion Date

2017-01-19

Brief Summary

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The investigators aim to explore obese cardiomyopathy by studying contractile twitch force, sarcomere sensitivity to calcium and mitochondrial function in atrial myocardial samples of patients grouped according to their body mass index, i.e. normal weight, overweight and obese.

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Detailed Description

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Obesity is associated with the development of heart failure, regardless of coronary artery disease or other comorbidities.

Right atrial samples obtained from patients undergoing cardiac surgery and presenting no sign of clinical cardiomyopathy will be grouped according to patient's body mass index. Atrial trabeculae will be explored to dissect out the respective contribution of (i) sarcoplasmic reticulum dysfunction (isometric twitch force contraction analysis), (ii) abnormal sarcomere sensitivity to calcium assessed in permeabilized fibers and (iii) mitochondrial dysfunction to intrinsec contractile dysfunction of myocardium in obese patients.

Conditions

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Obesity Heart Failure

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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obese patients

patients with BMI \> 30

functional tissu atrial analysis

Intervention Type OTHER

no obese patients

norma weight patient (BMI\<25) overweight patients ( 25\< BMI \>30)

functional tissu atrial analysis

Intervention Type OTHER

Interventions

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functional tissu atrial analysis

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patient schedulled for coronary artery bypass graft surgery or aortic valve replacement surgery with extracorporeal circulation
* must be over 18 years of age
* must be able to read and understand the consent form in French
* must be in sinus rhythm at inclusion time