Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
300 participants
OBSERVATIONAL
2015-03-31
Brief Summary
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Detailed Description
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The aim of this study is to compare telomere length, aggregate formation, and senescence markers in the syncytiotrophoblast of placentas from complicated pregnancy with placentas from normal pregnancy.
Telomere lenght and aggregate formation will be assessed by the fluorescent intensity of telomere FISH.
Senescence will be assessed by immunohistochemistry for the markers - SAHF, cyclin dependent kinase inhibitors p16/p21, HLAX, ERVWE1, SA-B-gal.
The study groups
1. A retrospective arm - paraffin blocks which were collected over the years from placentas from complicated pregnancy ( intrauterine growth restriction, preeclampsia , placenta accrete) will be compared to blocks of placentas from normal pregnancies.
2. The prospective arm - placental from complicated pregnancy ( intrauterine growth restriction, preeclampsia , placenta accrete) . Will be compared to placentas of normal pregnancies.
3. A laboratory model based on human placenta cell cultures
Conditions
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Study Design
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CASE_CONTROL
Study Groups
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normal pregnancy
placental from normal pregnancy
No interventions assigned to this group
complacted pregnancy
placental from complicated pregnancy ( intrauterine growth restriction, preeclampsia , placenta accrete
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
45 Years
FEMALE
Yes
Sponsors
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Meir Medical Center
OTHER
Responsible Party
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Other Identifiers
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0202-14-MMC
Identifier Type: -
Identifier Source: org_study_id
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