Endoscopic Full Thickness Resection in the Lower GI Tract With the "Full Thickness Resection Device"

NCT ID: NCT02362126

Last Updated: 2015-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-02-28

Study Completion Date

2017-02-28

Brief Summary

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Observational prospective multicenter study to investigate efficacy and safety of endoscopic full thickness resection in the lower GI tract using a novel over-the-scope full thickness resection device.

Detailed Description

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The FTRD ("Full Thickness Resection Device", Ovesco Endoscopy, Tübingen, Germany) is an over the scope device consisting of a transparent cap with a preloaded monofilament snare and and a 14 mm modified Over-the-scope Clip. The device is CE marked for full thickness resection in the lower GI tract.

The study was designed to investigate efficacy and safety of this device for full thickness resection of colorectal lesions.

Conditions

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Colorectal Adenomas Submucosal Tumors

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients undergoing EFTR

Patients with non-lifting adenomas, adnomas at difficult anaotomic locations , T1-carcinomas or submucosal colorectal tumors

Endoscopic full thickness resection (EFTR)

Intervention Type DEVICE

Patients undergo EFTR using the FTRD

Interventions

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Endoscopic full thickness resection (EFTR)

Patients undergo EFTR using the FTRD

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 y
* Adenoma with negtive lifting sign
* Adenoma involving or next to a diverticulum
* Adenoma involving or next to the appendical orifice
* T1 carcinoma with indication for endoscopic (re-)resection
* Subepithelial colorectal tumor with indication for resection

Exclusion Criteria

* Lesions \>3 cm
* T1 carcinomas with known high-risk features (submucosal infiltration\>1000 um, invasion of lymphatic vessels, poor differentiation (G3))
* Lesions in the upper GI tract
* Patients with colorectal stenosis
* Patinets not able to undergo informed consent
* Pregnancy
* Patients with urgent indication for dual thrombocyte aggregation inhibition
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ovesco Endoscopy AG

INDUSTRY

Sponsor Role collaborator

Kliniken Ludwigsburg-Bietigheim gGmbH

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Karel Caca, MD, PhD

Role: STUDY_CHAIR

Klinikum Ludwigsburg, Department of Gastroenterology

Arthur R Schmidt, MD

Role: PRINCIPAL_INVESTIGATOR

Klinikum Ludwigsburg, Department of Gastroenterology

Locations

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Klinikum Ludwigsburg

Ludwigsburg, Baden-Wurttemberg, Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Arthur R Schmidt, MD

Role: CONTACT

0049 (0) 7141 99 67201

Karel Caca, MD, PhD

Role: CONTACT

0049 (0) 7141 99 67201

Facility Contacts

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Arthur Schmidt, MD

Role: primary

+49-7141-9967201

Karel Caca, MD, PhD

Role: backup

+49-7141-9967201

References

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Schurr MO, Baur FE, Krautwald M, Fehlker M, Wehrmann M, Gottwald T, Prosst RL. Endoscopic full-thickness resection and clip defect closure in the colon with the new FTRD system: experimental study. Surg Endosc. 2015 Aug;29(8):2434-41. doi: 10.1007/s00464-014-3923-x. Epub 2014 Oct 16.

Reference Type BACKGROUND
PMID: 25318369 (View on PubMed)

Schmidt A, Damm M, Caca K. Endoscopic full-thickness resection using a novel over-the-scope device. Gastroenterology. 2014 Oct;147(4):740-742.e2. doi: 10.1053/j.gastro.2014.07.045. Epub 2014 Jul 30. No abstract available.

Reference Type BACKGROUND
PMID: 25083605 (View on PubMed)

Kuellmer A, Behn J, Beyna T, Schumacher B, Meining A, Messmann H, Neuhaus H, Albers D, Birk M, Probst A, Faehndrich M, Frieling T, Goetz M, Thimme R, Caca K, Schmidt A. Endoscopic full-thickness resection and its treatment alternatives in difficult-to-treat lesions of the lower gastrointestinal tract: a cost-effectiveness analysis. BMJ Open Gastroenterol. 2020 Aug;7(1):e000449. doi: 10.1136/bmjgast-2020-000449.

Reference Type DERIVED
PMID: 32816955 (View on PubMed)

Schmidt A, Beyna T, Schumacher B, Meining A, Richter-Schrag HJ, Messmann H, Neuhaus H, Albers D, Birk M, Thimme R, Probst A, Faehndrich M, Frieling T, Goetz M, Riecken B, Caca K. Colonoscopic full-thickness resection using an over-the-scope device: a prospective multicentre study in various indications. Gut. 2018 Jul;67(7):1280-1289. doi: 10.1136/gutjnl-2016-313677. Epub 2017 Aug 10.

Reference Type DERIVED
PMID: 28798042 (View on PubMed)

Other Identifiers

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WALL-RESECT

Identifier Type: -

Identifier Source: org_study_id

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