Endoscopic Resection of Non-ampullary Duodenal Adenomas: Endoscopic Mucosal Resection (EMR) vs. Endoscopic Full-thickness Resection With the 'Duodenal Full-thickness Resection Device' (dFTRD)

NCT ID: NCT03559231

Last Updated: 2018-06-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-12

Study Completion Date

2021-05-12

Brief Summary

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Prospective, randomized multi-center trial. Comparison of Endoscopic Mucosal Resection (EMR) versus Endoscopic Full-Thickness Resection with the duodenal Full-Thickness Resection Device (dFTRD) of non-ampullary duodenal adenomas.

Detailed Description

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Prospective, randomized multi-center trial. Comparison of Endoscopic Mucosal Resection (EMR) versus Endoscopic Full-Thickness Resection with the duodenal Full-Thickness Resection Device (dFTRD) of non-ampullary duodenal adenomas.

Conditions

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Duodenal Adenoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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dFTRD

Endoscopic full-thickness resection of the duodenal adenoma with the 'duodenal Full-Thickness resection device' (dFTRD).

Group Type EXPERIMENTAL

dFTRD

Intervention Type PROCEDURE

Duodenal Full-Thickness Resection

EMR

Endoscopic Mucosal Resection (EMR) of the duodenal adenoma (=standard therapy).

Group Type ACTIVE_COMPARATOR

EMR

Intervention Type PROCEDURE

Endoscopic Mucosal Resection

Interventions

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dFTRD

Duodenal Full-Thickness Resection

Intervention Type PROCEDURE

EMR

Endoscopic Mucosal Resection

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* duodenal adenoma
* age 18 or older
* written informed consent

Exclusion Criteria

* duodenal adenomas with a size \> 25 mm
* duodenal adenomas with 20 mm or less distance to the major and/or minor duodenal papilla
* presence of two or more duodenal adenomas
* suspected or histologically confirmed malignancy
* tumor disease (exception: after successful curative treatment)
* conditions/diseases of the upper GI-tract that impair advancing of the devices into the duodenum
* moribund patient
* pregnancy and breastfeeding
* patients that cannot give informed consent (e.g. psychiatric disorders, language barrier,...)
* other contraindications for duodenal resections
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kliniken Ludwigsburg-Bietigheim gGmbH

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Karel Caca, MD, PhD

Role: STUDY_CHAIR

Klinikum Ludwigsburg

Locations

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Klinikum Ludwigsburg

Ludwigsburg, Baden-Wurttemberg, Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Markus Bauder, MD

Role: CONTACT

+49(0)7141-99-67201

Karel Caca, MD, PhD

Role: CONTACT

+49(0)7141-99-67201

Facility Contacts

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Karel Caca, Prof. Dr. med.

Role: primary

+49(0)7141-99-67201

Sandra Wennemuth

Role: backup

+49(0)7141-99-94473

Other Identifiers

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DUO-RESECT

Identifier Type: -

Identifier Source: org_study_id

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