Detection and Treatment of Sarcopenia and Myosteatosis in Older African Americans

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

136 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-01

Study Completion Date

2023-09-01

Brief Summary

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The objectives of this study are to: 1) validate a rapid, portable, cost-effective method for screening myosteatosis and sarcopenia using diagnostic ultrasound, and 2) investigate a novel approach to progressive resistance exercise involving eccentric muscle actions that will counter the local effects of myosteatosis and sarcopenia in African Americans.

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Detailed Description

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The rationale for this study is the need to proactively address health disparities associated with age-related skeletal muscle dysfunction. Age-related changes in muscle may be characterized by sarcopenia (i.e., loss of muscle mass) and/or myosteatosis (i.e., excessive intramuscular adipose tissue). These changes may result in physical impairments that may be exacerbated by the lack of a formal screening and diagnosis process for older adults in standard healthcare settings. Myosteatosis may compound the effects of sarcopenia and play a significant role the age-related functional decline and higher incidence of type 2 diabetes observed in African Americans in comparison to other ethnic/racial groups. The initial phase of the study will involve the assessment of older African Americans (n = 70) to characterize muscle size and quality in comparison to a younger reference group (n = 70). Participants randomly selected from the older subject pool will be assigned to either the Eccentric Exercise Group or the Concentric Exercise Group for 12 weeks of a supervised strengthening exercise regimen.

Conditions

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Sarcopenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Eccentric Exercise

Supervised strengthening exercise using eccentric muscle actions.

Group Type EXPERIMENTAL

Eccentric Exercise

Intervention Type BEHAVIORAL

Submaximal progressive resistance exercise (PRE) using eccentric muscle actions for the knee extensors/flexors will be performed for 10 repetitions, 3 to 4 sets, twice per week for 12 weeks.

Concentric Exercise

Supervised strengthening exercise using concentric muscle actions.

Group Type ACTIVE_COMPARATOR

Concentric Exercise

Intervention Type BEHAVIORAL

Submaximal progressive resistance exercise (PRE) using concentric muscle actions for the knee extensors/flexors will be performed for 10 repetitions, 3 to 4 sets, twice per week for 12 weeks.

Interventions

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Eccentric Exercise

Submaximal progressive resistance exercise (PRE) using eccentric muscle actions for the knee extensors/flexors will be performed for 10 repetitions, 3 to 4 sets, twice per week for 12 weeks.

Intervention Type BEHAVIORAL

Concentric Exercise

Submaximal progressive resistance exercise (PRE) using concentric muscle actions for the knee extensors/flexors will be performed for 10 repetitions, 3 to 4 sets, twice per week for 12 weeks.

Intervention Type BEHAVIORAL

Other Intervention Names

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Negative work training Conventional strength training

Eligibility Criteria

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Inclusion Criteria

* An African American adult.
* Between 18 and 30 years of age, or between 65 and 85 years of age.
* Able to independently walk at home and in your community (use of an assistive device like a cane or a walker is acceptable).

Exclusion Criteria

* Uncontrolled hypertension or other cardiovascular disease.
* A Body Mass Index of 32.5 or above may be an exclusion criterion if the X-ray technician determines that dimensions of the scanning bed are not adequate for a reliable examination.
* A musculoskeletal condition that would stop you from performing the physical assessment tests.
* Muscle weakness due to neurological disease or injury (such as stroke or spinal cord injury).
* Moderate to severe sepsis (blood infection) or edema (such as swelling of a limb).
* Been hospitalized over the last three months.
* History of a broken arm or leg bone because of osteoporosis.

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes